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Article
Open AccessExtracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells
The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their microenvironment. One method that cells use for interc...
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Chapter
Total Synthesis of Glycosylated Proteins
Glycoproteins are an important class of naturally occurring biomolecules which play a pivotal role in many biological processes. They are biosynthesized as complex mixtures of glycoforms through post-translati...
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Article
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
High-throughput screening systems that better mimic the physiological complexity of diseased tissues may aid the discovery of more efficacious compounds. A co-culture system that mimics the microenvironment of...
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Article
Nrf2 regulates haematopoietic stem cell function
Van den Brink and colleagues show that Nrf2, a regulator of the oxidative stress response, is required for several aspects of haematopoietic stem cell maintenance. Loss of Nrf2 results in the hyper-proliferati...
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Chapter
In Vitro Development of Megakaryocytes and Platelets
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Article
Hematopoietic growth factor receptors
The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which includ...
