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Living Reference Work Entry In depth
Assessing Pyruvate Carboxylase Flux as a Mechanistic Biological Marker in Fasting
Pyruvate carboxylase (PC) is an enzyme that catalyzes pyruvate carboxylation for the formation of a tricarboxylic acid (TCA) cycle intermediate, oxaloacetate. It plays a major role in the regulation of glucone...
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Reference Work Entry In depth
Assessing Pyruvate Carboxylase Flux as a Mechanistic Biological Marker in Fasting
Pyruvate carboxylase (PC) is an enzyme that catalyzes pyruvate carboxylation for the formation of a tricarboxylic acid (TCA) cycle intermediate, oxaloacetate. It plays a major role in the regulation of glucone...
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Article
Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle
The role of pyruvate dehydrogenase in mediating lipid-induced insulin resistance stands as a central question in the pathogenesis of type 2 diabetes mellitus. Many researchers have invoked the Randle hypothesi...
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Chapter
Insights on Lactate Metabolism in Skeletal Muscle Based on 13C Dynamic Nuclear Polarization Studies
Despite the textbook pronouncements about muscle lactate (lac) as a glycolytic end-product, which many use to characterize a hypoxia threshold, and as a precursor for recycling in liver, recent studies have be...
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Chapter
Kinetic Modeling of Enzymatic Reactions in Analyzing Hyperpolarized NMR Data
Hyperpolarized (HP) 13C magnetic resonance is an emerging modality that provides a dramatically enhanced signal-to-noise ratio (SNR) over conventional magnetic resonance imaging (MRI). By injecting a biologically...
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Article
Open AccessHyperpolarized 15N-labeled, deuterated tris(2-pyridylmethyl)amine as an MRI sensor of freely available Zn2+
Dynamic nuclear polarization (DNP) coupled with 15N magnetic resonance imaging (MRI) provides an opportunity to image quantitative levels of biologically important metal ions such as Zn2+, Mg2+ or Ca2+ using appr...
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Article
Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer: First Experience in a Canine Prostate Cancer Model
To assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine pr...
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Article
Open AccessIn vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma
Altered branched-chain amino acids (BCAAs) metabolism is a distinctive feature of various cancers and plays an important role in sustaining tumor proliferation and aggressiveness. Despite the therapeutic and d...
