14 Result(s)
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Article
Open AccessDistinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults
Pneumococcal infections cause serious illness and death among older adults. The capsular polysaccharide vaccine PPSV23 and conjugated alternative PCV13 can prevent these infections; yet, underlying immunologic...
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MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
Regenerative stem cell–like memory (TSCM) CD8+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have naive phenotype with self-renewability,...
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Article
Sestrins induce natural killer function in senescent-like CD8+ T cells
Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly differentiated cells that exhibit...
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Article
Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE pro...
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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of l...
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Pathophysiology of T follicular helper cells in humans and mice
In this Review, Ueno, Vinuesa and Banchereau discuss the similarities and differences between mouse and human follicular helper T cells (TFH cells) and discuss their role in response to vaccines and in disease pa...
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The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
The factors that drive the differentiation of human follicular helper cells remain largely undefined. Ueno and colleagues show that TGF-β complements STAT3- and STAT4-activating cytokines to promote the initia...
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From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
Feedback regulatory circuits provided by regulatory T cells (Treg cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory...
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Data management: it starts at the bench
Data management has been neglected but should be made an integral activity in all research laboratories. Chaussabel and colleagues discuss how to implement this at the bench.
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Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor RORγt. Cupedo's group identifies RORγt+ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier a...
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Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
Although plasmacytoid dendritic cells (pDCs) respond to virus replication in a nonspecific way by producing large amounts of type I interferon, a rapid, direct function for pDCs in activating antiviral lymphoc...
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Langerhans cells: daughters of monocytes
Precursors of specialized skin dendritic cells called Langerhans cells are derived from specific bone marrow–derived monocyte precursors that migrate to the skin and differentiate into these important immune s...
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Dendritic cells as therapeutic vaccines against cancer
Vaccines against cancer aim to induce both tumour-specific effector T cells that can reduce the tumour mass and tumour-specific memory T cells that can control...
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IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
Monocytes can give rise to either antigen presenting dendritic cells (DCs) or scavenging macrophages. This differentiation is initiated when monocytes cross the endothelium. But the regulation of DC and macrop...
