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  1. No Access

    Article

    Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34+ progenitor-derived dendritic cells

    Between March 1999 and May 2000, 18 HLA-A*0201+ patients with metastatic melanoma were enrolled in a phase I trial using a dendritic cell (DC) vaccine generated by culturing CD34+ hematopoietic progenitors. This ...

    Joseph W. Fay, A. Karolina Palucka, Sophie Paczesny… in Cancer Immunology, Immunotherapy (2006)

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    Chapter

    In Vitro Regulation of Dendritic Cell Development and Function

    Human and murine dendritic cells (DC) can now be generated in vitro in large numbers by culturing progenitor cells. The establishment of such culture systems will allow clarification of the relationship between d...

    Christophe Caux, Jacques Banchereau in Blood Cell Biochemistry (1996)

  3. No Access

    Chapter

    Regulation of Peripheral B-Cell Growth and Differentiation

    The life histories of B lymphocytes and T lymphocytes share many similar features. They derive from immature precursor cells and use similar genes and strategy to encode, assemble, and select their surface ant...

    Jacques Banchereau, Pierre Garrone, Yong-Jun Liu in Blood Cell Biochemistry (1996)

  4. No Access

    Chapter

    Inhibitory Effect of IL-10 on Human Langerhans Cell Antigen Presenting Function

    IL-10 has been previously described by Mossman and coworkers as a product of murine Th2 clones that inhibits the production of cytokines by Thl clones (1). Accumulated evidence now indicate that this cytokine ...

    Josette Péguet-Navarro, Corinne Moulon… in Dendritic Cells in Fundamental and Clinica… (1995)

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    Chapter

    Human Dendritic Cells Can Drive CD40-Activated slgD+ B Cells to Mount Mucosal-Type Humoral Response

    Following tissue injury, invading antigens are captured by dendritic cells (DC) which migrate to secondary lymphoid organs where they initiate immune responses that involve triads composed of T cells, B cells ...

    Jérôme Fayette, Bertrand Dubois… in Dendritic Cells in Fundamental and Clinica… (1995)

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    Chapter

    Human Follicular Dendritic Cells Promote Both Proliferation and Differentiation of CD40 Activated B Cells

    Follicular dendritic cells (FDCs) are unique stromal cells within the germinal centers, where intensive B cell proliferation was identified. The main feature of these cells is their capacity to trap antigenant...

    Géraldine Grouard, Odette de Bouteiller… in Dendritic Cells in Fundamental and Clinica… (1995)

  7. No Access

    Chapter

    Activation of Primary Allogeneic CD8+ T Cells by Dendritic Cells Generated in Vitro from CD34+ Cord Blood Progenitor Cells

    Dendritic cells (DC) have been shown to be the most potent antigen presenting cells (APC). Due to the difficulty to obtain large numbers of mature dendritic cells, several groups have developed ways to generat...

    Martine Wettendorff, Catherine Massacrier… in Dendritic Cells in Fundamental and Clinica… (1995)

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    Chapter

    Human Dendritic Cells Enhance Growth and Differentiation of CD40 Activated B Cells

    During an immune response, dendritic cells (DC) capture the antigen at site of injury, and migrate through the afferent lymph stream to the lymph-nodes where they efficiently activate naive T cells. This T cel...

    Bertrand Dubois, Jérôme Fayette… in Dendritic Cells in Fundamental and Clinica… (1995)

  9. No Access

    Chapter

    Transforming Growth Factor Beta (TGFβ) Directs IgA1 and IgA2 Switching in Human Naive B Cells

    Until recently, there was no experimental system that permitted the study of soluble factors capable of inducing human B lymphocytes to switch isotypes in vitro. Unlike lipopolysaccharide which is currently used ...

    Francine Briere, Thierry Defrance, Beatrice Vanbervliet… in Advances in Mucosal Immunology (1995)