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  1. No Access

    Article

    Uveal melanoma cell-based vaccines express MHC II molecules that traffic via the endocytic and secretory pathways and activate CD8+ cytotoxic, tumor-specific T cells

    We are exploring cell-based vaccines as a treatment for the 50% of patients with large primary uveal melanomas who develop lethal metastatic disease. MHC II uveal melanoma vaccines are MHC class I+ uveal melanoma...

    Jacobus J. Bosch, Uzoma K. Iheagwara, Sarah Reid… in Cancer Immunology, Immunotherapy (2010)

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    Article

    Lung cancer patients’ CD4+ T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells

    Advanced non-small cell lung cancer (NSCLC) remains an incurable disease. Immunotherapies that activate patients’ T cells against resident tumor cells are being developed; however, these approaches may not be ...

    Minu K. Srivastava, Jacobus J. Bosch, James A. Thompson… in Cancer Immunology, Immunotherapy (2008)

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    Article

    The absence of invariant chain in MHC II cancer vaccines enhances the activation of tumor-reactive type 1 CD4+ T lymphocytes

    Activation of tumor-reactive T lymphocytes is a promising approach for the prevention and treatment of patients with metastatic cancers. Strategies that activate CD8+ T cells are particularly promising because of...

    James A. Thompson, Minu K. Srivastava, Jacobus J. Bosch… in Cancer Immunology, Immunotherapy (2008)