21 Result(s)

Article

Endoplasmic Reticulum Protein 29 Protects Axotomized Neurons from Apoptosis and Promotes Neuronal Regeneration Associated with Erk Signal

Spinal cord injury (SCI) results in a series of severe dysfunction of sensory and motor functions, while the molecular mechanisms that cause these dysfunctions remain elusive. Using proteomics technology, West...

Yun-Hui Zhang, Visar Belegu, Yu Zou, Fang Wang, Bao-Jiang Qian… in Molecular Neurobiology (2015)

Article

Axon Myelination and Electrical Stimulation in a Microfluidic, Compartmentalized Cell Culture Platform

Axon demyelination contributes to the loss of sensory and motor function following injury or disease in the central nervous system. Numerous reports have demonstrated that myelination can be achieved in neuron...

In Hong Yang, Devin Gary, Misti Malone, Stephen Dria… in NeuroMolecular Medicine (2012)

Article

Measuring Birth Weight in Develo** Countries: Does the Method of Reporting in Retrospective Surveys Matter?

This study investigates the patterns of recording birth weight data in retrospective surveys and their influence on birth weight estimates in less developed countries. We hypothesise that the method of reporti...

Andrew A. R. Channon, Sabu S. Padmadas… in Maternal and Child Health Journal (2011)

Article

The Manifest Association Structure of the Single-Factor Model: Insights from Partial Correlations

The association structure between manifest variables arising from the single-factor model is investigated using partial correlations. The additional insights to the practitioner provided by partial correlatio...

Maria de Fátima Salgueiro, Peter W. F. Smith, John W. McDonald in Psychometrika (2008)

Chapter

Embryonic Stem Cells and Neurogenesis

The convergence of genomic technologies, high-throughput screening techniques, the availability of pluripotent embryonic stem (ES) cell lines provides an unprecedented opportunity to identify the molecular mec...

Robin L. Wesselschmidt, John W. McDonald in Neural Development and Stem Cells (2006)

Article

Markov chain Monte Carlo exact inference for binomial and multinomial logistic regression models

We develop Metropolis-Hastings algorithms for exact conditional inference, including goodness-of-fit tests, confidence intervals and residual analysis, for binomial and multinomial logistic regression models. ...

Jonathan J. Forster, John W. McDonald, Peter W. F. Smith in Statistics and Computing (2003)

Chapter

ES Cells and Neurogenesis

The scientific potential of embryonic stem (ES) cells was harnessed in 1981, when ES cells were first derived from mice, marking the birth of transgenic animal technology (1,2; Table 1). However, the concept of a...

John W. McDonald in Stem Cells and CNS Development (2001)

Article

Mixture modelling of recurrent event times with long-term survivors: Analysis of Hutterite birth intervals

We propose a mixture model that combines a discrete-time survival model for analyzing the correlated times between recurrent events, e.g. births, with a logistic regression model for the probability of never e...

John W. McDonald, Alessandro Rosina in Statistical Methods and Applications (2001)

Article

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

Transplantation approaches using cellular bridges^1,2, fetal central nervous system cells^3,4,5, fibroblasts expressing neurotrophin-3 (ref. 6), hybridoma cells expressing inhibitory protein-blocking antibodies⁷, o...

John W. McDonald, **ao-Zhong Liu, Yun Qu, Su Liu, Shannon K. Mickey… in Nature Medicine (1999)

Article

Exact tests for two-way symmetriccontingency tables

A two-way contingency table in which both variables have the same categories is termed a symmetric table. In many applications, because of the social processes involved, most of the observations lie on the mai...

JOHN W. McDONALD, DAVID C. DeROURE, DANIUS T. MICHAELIDES in Statistics and Computing (1998)

Article

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

Little is known of the molecular mechanisms that trigger oligodendrocyte death and demyelination in many acute central nervous system insults. Since oligodendrocytes express functional α-amino-3-hydroxy-5-meth...

John W. Mcdonald, Sandy P. Althomsons, Krzysztof L. Hyrc, Dennis W. Choi… in Nature Medicine (1998)

Article

Exact conditional tests for incomplete contingency tables: estimating attained significance levels

A Monte Carlo exact conditional test of quasi-independence in two-way incomplete contingency tables is proposed. The null distribution of a random table under quasiindependence is derived. This distribution de...

Peter W. F. Smith, John W. McDonald in Statistics and Computing (1995)

Chapter and Conference Paper

Simulate and Reject Monte Carlo Exact Conditional Tests for Quasi-independence

In a two-way contingency table, the null hypothesis of quasi-independence (QI) usually arises for two main reasons: 1) some cells involve structural zeros or 2) interest is focused on part of the table, e.g., ...

Peter W. F. Smith, John W. McDonald in Compstat (1994)

Article

Birth interval and family effects on postneonatal mortality in Brazil

In this paper random-effects logistic models are used to analyze the effects of the preceding birth interval on postneonatal mortality in Brazil, controlling for the correlation of survival outcomes between si...

Siân L. Curtis, Ian Diamond, John W. McDonald in Demography (1993)

Chapter

Managing Complexity Through Small Group Dynamics

The aim of this chapter is to show that it is possible to achieve global consensus on complex and sensitive international issues such as the environment, population planning or telecommunications policy, to gi...

John W. McDonald in Conflict: Readings in Management and Resolution (1990)

Chapter and Conference Paper

Bootstrap Goodness-of-Link Testing in Generalized Linear Models

Bootstrap methodology is used to compare the fit of generalized linear models with different link functions to binary response data. The difference in deviance between two non-nested models is used as a test s...

Michael J. Cole, John W. McDonald in Statistical Modelling (1989)

Chapter and Conference Paper

Beta-Geometric Modelling of Birth Intervals Using GLIM

A discrete-time survival model allowing for both observed and unobserved time-varying heterogeneity in risk was recently proposed by Weinberg and Gladen (1986). The basic beta- geometric model and its extensio...

Peter J. Egger, John W. McDonald in Statistical Modelling (1989)

Article

Proportional hazards models for current status data: Application to the study of differentials in age at weaning in Pakistan

Ian D. Diamond, John W. McDonald, Iqbal H. Shah in Demography (1986)