![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Chapter
Carotid Chemoreceptor Responses to Hypoxia and Hypercapnia in Develo** Kittens
Breathing pattern in the newborn is characterized by irregularity and instability, the ventilatory (VE) defense against hypoxia is not sustained (Bureau et al, 1982, 1984, 1985; Lawson and Long 1983; Martin-Bo...
-
Chapter
Time-Dependence of Hyperoxia-Induced Impairment in Peripheral Chemoreceptor Activity and Glomus Cell Calcium Response
In mammals, transient exposure to hyperoxia for a period of weeks during perinatal life leads to impairment of the ventilatory response to acute hypoxia, which may persist long beyond the duration of the hyper...
-
Chapter
Modification of Relative Gene Expression Ratio Obtained from Real Time qPCR with Whole Carotid Body by Using Mathematical Equations
Quantitative real time PCR (qPCR) is a common tool used to compare the relative gene expression between treated/untreated cells, different types of tissues, or immature/mature organs. When homogeneous cells ar...
-
Chapter
Fluoresceinated Peanut Agglutinin (PNA) is a Marker for Live O2 Sensing Glomus Cells in Rat Carotid Body
Experiments using live dissociated carotid body (CB) cells for patch clam**, [Ca++]i or other measurements require positive identification of the cell being recorded. At present, cell morphology is usually empl...
-
Article
Open AccessFLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition
Cancer metastasis remains a significant challenge and the leading cause of cancer-associated deaths. It is postulated that during metastasis cells undergo epithelial-to-mesenchymal transition (EMT), a process ...
-
Article
Open AccessPhox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models
Loss- and gain-of-function variants in the gene encoding KCNQ2 channels are a common cause of developmental and epileptic encephalopathy, a condition characterized by seizures, developmental delays, breathing ...