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  1. Article

    Open Access

    Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models

    Loss- and gain-of-function variants in the gene encoding KCNQ2 channels are a common cause of developmental and epileptic encephalopathy, a condition characterized by seizures, developmental delays, breathing ...

    J. Soto-Perez, C. M. Cleary, C. R. Sobrinho, S. B. Mulkey… in Nature Communications (2023)

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  2. Article

    Open Access

    FLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition

    Cancer metastasis remains a significant challenge and the leading cause of cancer-associated deaths. It is postulated that during metastasis cells undergo epithelial-to-mesenchymal transition (EMT), a process ...

    C F Abshire, J L Carroll, A-M Dragoi in Oncogenesis (2016)

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  3. No Access

    Chapter

    Time-Dependence of Hyperoxia-Induced Impairment in Peripheral Chemoreceptor Activity and Glomus Cell Calcium Response

    In mammals, transient exposure to hyperoxia for a period of weeks during perinatal life leads to impairment of the ventilatory response to acute hypoxia, which may persist long beyond the duration of the hyper...

    J.L. Carroll, I. Kim, H. Dbouk, D.J. Yang, R.W. Bavis… in Arterial Chemoreceptors (2009)

  4. No Access

    Chapter

    Modification of Relative Gene Expression Ratio Obtained from Real Time qPCR with Whole Carotid Body by Using Mathematical Equations

    Quantitative real time PCR (qPCR) is a common tool used to compare the relative gene expression between treated/untreated cells, different types of tissues, or immature/mature organs. When homogeneous cells ar...

    J.H. Kim, I. Kim, J.L. Carroll in Arterial Chemoreceptors (2009)

  5. No Access

    Chapter

    Fluoresceinated Peanut Agglutinin (PNA) is a Marker for Live O2 Sensing Glomus Cells in Rat Carotid Body

    Experiments using live dissociated carotid body (CB) cells for patch clam**, [Ca++]i or other measurements require positive identification of the cell being recorded. At present, cell morphology is usually empl...

    I. Kim, D.J. Yang, D.F. Donnelly, J.L. Carroll in Arterial Chemoreceptors (2009)

  6. No Access

    Chapter

    Carotid Chemoreceptor Responses to Hypoxia and Hypercapnia in Develo** Kittens

    Breathing pattern in the newborn is characterized by irregularity and instability, the ventilatory (VE) defense against hypoxia is not sustained (Bureau et al, 1982, 1984, 1985; Lawson and Long 1983; Martin-Bo...

    J. L. Carroll, R. S. Fitzgerald in Neurobiology and Cell Physiology of Chemoreception (1993)