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Article
Detection of p53 tumor-suppressor-gene protein in bladder tumors and prostate cancer: possible clinical implications
For a variety of human malignancies such as breast cancer and cancer of the prostate, p53 oncoprotein overexpression indicating an alteration of the p53 tumorsuppressor gene has been described as a prognostic fac...
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Article
p53 immunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder
Although patients with superficial bladder cancer (Ta, T1) have a generally good prognosis, those patients who develop muscle-invasive tumours or metastatic disease at recurrence do poorly clinically. In the c...
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Article
New aspects on the identification of genetic alterations and prognostically important biological parameters in renal cell cancer
The observation of extremely variable clinical courses for patients with renal cell carcinomas of an identical pathological stage as well as a comparable histological differentiation resp. growth pattern stron...
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Article
Open AccessPredictive value of decreased p27Kip1 protein expression for the recurrence-free and long-term survival of prostate cancer patients
The p27Kip1 gene has been identified as inductor of cell cycle arrest at the G1 checkpoint to prevent entry of somatic cells into the S phase of the cell cycle when substantial DNA damage has occurred. It has bee...
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Article
Detection of viral HPV 16 DNA in prostate cancer and benign prostatic hyperplasia by quantitative PCR-directed analysis
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Article
P53 regulated maspin protein expression determines recurrence-free survival of patients with localised prostate cancer
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Article
Correlation of bFGF expression in renal cell cancer with clinical and histopathological features by tissue microarray analysis and measurement of serum levels
The prognostic value of bFGF for surgically treated renal cell cancer (RCC) patients was evaluated by immunohistochemistry (IHC) and the tissue microarray technique (TMA). Additionally, preoperative serum bFGF...
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Article
Tissue microarrays: applications in urological cancer research
Tissue microarrays (TMAs) are used to simultaneously study the expression of proteins in hundreds of tissue samples, offering the important advantage to screen large tissue banks for biomarker expression and t...
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Article
Positron emission tomography (PET) in the urooncological evaluation of the small pelvis
Positron emission tomography (PET) with the use of (18F)2-fluoro-d-2-desoxyglucose (FDG) has been investigated to be a highly sensitive and specific imaging modality in the diagnostic of primary and recurrent tum...
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Article
Nachweis hypermethylierter Genpromotoren zur Diagnostik des Prostatakarzinoms
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Article
Expressionscharakterisierung von Zellzyklusproteinen im Nierenzellkarzinom zur Identifizierung molekularer Prognostikatoren
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Article
Expression des „Corticotropin releasing faktor rezeptors 2“ (CRFR2) in der humanen Prostata
Die Expression von Urocortin (Ucn), ein aus 40 Aminosäuren bestehendes Neuropeptid, wurde im Prostatagewebe von Patienten mit BPH berichtet. In verschiedenen Organen ist Ucn bei der Regulation von lokalen Entz...
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Article
Galectin-Expression an urologischen Tumoren
Galectine sind eine Gruppe von 15 Proteinen, die sowohl intra- als auch extrazellulär an bestimmte Kohlenhydratreste binden können und dabei eine wichtige Rolle bei der Regulation des Zellzyklus spielen. So wu...
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Article
Open AccessHsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
Whether methylation of the microRNA (mir)-124-3 CpG island is of relevance for the clinical course of a solid cancer and whether it shows association with clinicopathology or survival of patients with renal cell ...
