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Article
Open AccessExpression patterns of the immune checkpoint ligand CD276 in urothelial carcinoma
CD276 is an immune checkpoint molecule. Elevated CD276 expression by urothelial carcinoma is associated with poor prognosis, but little is known about its expression across different tumor stages. We therefore...
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Article
No influence of smoking status on the performance of urine markers for the detection of bladder cancer
The performance of urinary markers for detecting bladder cancer (BC) is influenced by various factors. The aim of the present study was to evaluate the influence of smoking habits on the performance of four co...
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Article
Prostate cancer gene 3 (PCA3) is of additional predictive value in patients with PI-RADS grade III (intermediate) lesions in the MR-guided re-biopsy setting for prostate cancer
Multiparametric magnetic resonance imaging (mpMRI) improves diagnostic accuracy in re-biopsies of men with prostate cancer (PC) suspicion, but predictive value is limited despite the use of the new Prostate I...
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Article
Komplexe Residualtumoren nach Chemotherapie bei nichtseminomatösen Keimzelltumoren
Die retroperitoneale Lymphadenektomie (RLA) ist die Therapie der Wahl bei Patienten mit metastasierendem Nichtseminom (NSGCT) nach Chemotherapie. Mit der Weiterentwicklung der laparoskopischen Operationstechni...
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Article
Laparoskopische Nierenteilresektion bei Nierentumoren
Ziel der Studie war die an unserer Klinik durchgeführten laparoskopischen Nierenteilresektionen (LPN) mit aktuellen Studien zur Nierenteilresektion zu vergleichen.
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Article
Influence of age on false positive rates of urine-based tumor markers
Several influencing factors on false positive rates (FPRs) of urine-based tumor markers in the detection of urothelial cancer (UC) have been identified. We evaluated age as a possible influencing factor.
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Article
Laparoskopisch retroperitoneale Lymphadenektomie bei Low-volume-Keimzelltumoren nach Chemotherapie
Die retroperitoneale Lymphadenektomie (RPLND) ist die Methode der Wahl zur Resektion von persistierenden Raumforderungen nach Chemotherapie bei Patienten mit fortgeschrittenen nicht-seminomatösen (NSGCT) oder ...
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Article
Prostatic peripheral nerve distribution may impact the functional outcome of nerve-sparing prostatectomy
To study microscopic patterns of remaining peripheral nerves (PN) after nerve-sparing (NS) radical prostatectomy (RP) and possible consequences for nerve preparation.
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Article
Open AccessHsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
Whether methylation of the microRNA (mir)-124-3 CpG island is of relevance for the clinical course of a solid cancer and whether it shows association with clinicopathology or survival of patients with renal cell ...
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Article
Kidney-specific cadherin correlates with the ontogenetic origin of renal cell carcinoma subtypes: an indicator of a malignant potential?
To evaluate retrospectively kidney-specific cadherin (Ksp-cad) expression in renal cell carcinoma (RCC) subtypes and oncocytoma in correlation with its ontogenetic origin of distal and proximal tubules and to ...
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Article
Akt signalling parameters are different in oncocytomas compared to renal cell carcinoma
Renal oncocytomas are assigned as benign tumours, and their detailed molecular mechanism is poorly characterised. Activation of the PKB/Akt pathway is assumed to contribute to the pathogenesis and progression ...
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Article
Patienten nach Primärtherapie eines klinisch lokal begrenzten Prostatakarzinoms
Die radikale Prostatektomie (RP) und die perkutane Strahlentherapie (ST) sind Primärtherapie des klinisch lokal begrenzten Prostatakarzinoms. In Anbetracht der zwei Therapieformen wird die Lebensqualität (LQ) ...
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Article
Alteration of bone sialoprotein expression in osseous metastasized renal cell carcinomas and the tumor surrounding tissue
Bone sialoprotein (BSP) regulates bone metabolism by directly influencing the activity of osteoblasts and osteoclasts. A significant correlation between the tissue expression of BSP in tumors and the occurrenc...
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Article
Open AccessEconomic aspects of bladder cancer: what are the benefits and costs?
Bladder cancer (BC) has the highest lifetime treatment costs per patient of all cancers. The high recurrence rate and ongoing invasive monitoring requirement are the key contributors to the economic and human ...
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Article
Interdisziplinäre Untersuchungen zur Verbesserung der Behandlungsqualität des Prostatakarzinoms
Beim Prostatakarzinom treten neben dem onkologischen Resultat in der Folge die Fragen nach der Lebensqualität zunehmend in den Vordergrund. Mit der Etablierung eines multidisziplinär kooperierenden Forschungsn...
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Article
„Tissue engineering“ und Stammzellforschung in der Urologie für den rekonstruktiven bzw. regenerativen Therapieansatz
Nachdem sich die rekonstruktive Urologie in den letzten Jahren neuen Gebieten gewidmet hat, konnten im Bereich „tissue engineering“, nach herausragenden Ergebnissen in der Grundlagenforschung, erste Erfolge in...
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Article
Alterations of neuropeptides in the human gut during peritonitis
Gastrointestinal motility is reduced during sepsis but the pathomechanism involved is poorly understood. We investigated the expression of substance P (SP) and vasoactive intestinal peptide (VIP) in the myente...
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Article
Stellenwert der Stammzelltherapie für die Behandlung der Belastungsinkontinenz
Nachdem sich in den letzten Jahren nicht nur der therapeutische Ansatz bezüglich der Belastungsinkontinenz grundlegend geändert hat, tritt der Wunsch stetig anwachsender Patientenzahlen nach der funktionellen ...
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Chapter and Conference Paper
Die Expression von motilitätshemmenden Neuropeptiden im menschlichen Dünndarm ist während einer Peritonitis signifikant erhöht
Gastrointestinal motility is significantly reduced during peritonits. However the pathomechanism is poorly understood. We investigated the expression of pro- and antikinetic neuropeptides in the neurons of the...
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Article
Tissue microarrays: applications in urological cancer research
Tissue microarrays (TMAs) are used to simultaneously study the expression of proteins in hundreds of tissue samples, offering the important advantage to screen large tissue banks for biomarker expression and t...
