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Article
Open AccessPractical applications of studies on the TSH receptor and TSH receptor autoantibodies
Studies on the TSH receptor (TSHR) have numerous practical applications in vitro and in vivo. For example human monoclonal autoantibodies (MAbs) to the TSHR are useful reagents for in vitro diagnostics. Measur...
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Article
Open AccessThe role of p21-activated kinase in the initiation of atherosclerosis
p21-activated kinase (PAK) has been implicated in the inflammatory activation of endothelial cells by disturbed fluid shear stress, which is the initiating stimulus in atherosclerosis. The study addresses whet...
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Article
Autologous bone marrow transplantation for children with AML in first remission
In Children's cancer group (CCG) 2891, newly diagnosed patients with AML were randomized between standard and intensive timing induction therapies. Patients in first remission who lacked an HLA matched family ...
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Article
Unravelling the genome: a review of molecular genetic research in schizophrenia
Schizophrenia is a common and complex mental illness that affects approximately 1% of the population worldwide. Despite intensive research over the years, the aetiology and pathogenesis of schizophrenia is poo...
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Article
Postremission therapy for children with acute myeloid leukemia: the children's cancer group experience in the transplant era
We reviewed consolidation therapy results and analyzed postremission outcomes for 1464 children less than 21 years old at diagnosis in five consecutive Children's Cancer Group acute myeloid leukemia trials bet...
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Reproducibility in retrospective grading of acute graft-versus-host disease after allogeneic marrow transplantation
We have undertaken a formal study to evaluate the reproducibility of retrospective assessments for grading the severity of acute GVHD. Using criteria previously established by the Seattle group, three reviewer...