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  1. Article

    Open Access

    A novel in vitro model of metastasis supporting passive shedding hypothesis from murine pancreatic cancer Panc-02

    Cancer metastasis is believed to happen through active intravasation but there might be also another way to metastasize. According to passive shedding hypothesis, proposed by Munn et al., tumor cells detach fr...

    M. P. Krzykawski, R. Krzykawska, M. Paw, J. Czyz, J. Marcinkiewicz in Cytotechnology (2019)

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  2. Article

    Open Access

    Expression and activity of hydrogen sulfide generating enzymes in murine macrophages stimulated with lipopolysaccharide and interferon-γ

    Murine macrophages of the J774A.1 line are hydrogen sulphide-producing cells with the primary role of γ-cystathionase (CTH) and secondary role of 3-mercaptopyruvate sulfurtransferase (limited by cysteine avail...

    Patrycja Bronowicka-Adamska, H. Jurkowska, A. Gawda… in Molecular Biology Reports (2019)

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  3. No Access

    Chapter and Conference Paper

    Comparative Analysis of Microbicidal and Anti-inflammatory Properties of Novel Taurine Bromamine Derivatives and Bromamine T

    Taurine, the most abundant free amino acid in leukocyte cytosol traps hypohalous acids (HOCl and HOBr) to produce N-chlorotaurine (taurine chloramine, NCT and N-bromotaurine (taurine bromamine, Tau-NHBr,) resp...

    M. Walczewska, A. Peruń, A. Białecka, M. Śróttek, W. Jamróz, P. Dorożyński… in Taurine 10 (2017)

  4. No Access

    Article

    The role of heme oxygenase-1 in down regulation of PGE2 production by taurine chloramine and taurine bromamine in J774.2 macrophages

    Taurine chloramine (TauCl) and taurine bromamine (TauBr), products of myeloperoxidase halide system, exert anti-inflammatory properties. TauCl was demonstrated to inhibit the production of a variety of pro-inf...

    R. Olszanecki, M. Kurnyta, R. Biedroń, P. Chorobik, M. Bereta… in Amino Acids (2008)

  5. No Access

    Article

    Heme oxygenase-1 participates in the anti-inflammatory activity of taurine chloramine

    Interleukin-6 (IL-6) and interleukin-8 (IL-8) are implicated in the pathogenesis of rheumatic diseases. In affected joints fibroblast-like synoviocytes (FLS) are the major source of these pro-inflammatory cyto...

    B. Muż, E. Kontny, J. Marcinkiewicz, W. Maśliński in Amino Acids (2008)

  6. No Access

    Article

    Comparison of taurine chloramine and taurine bromamine effects on rheumatoid arthritis synoviocytes

    Fibroblast-like synoviocytes (FLS) participate in rheumatoid arthritis (RA) chronic synovitis by producing pro-inflammatory cytokines (IL-6, IL-8), growth factors (VEGF) and other inflammatory mediators (PGE2, NO...

    E. Kontny, M. Chorąży-Massalska, W. Rudnicka, J. Marcinkiewicz, W. Maśliński in Amino Acids (2007)

  7. No Access

    Article

    Taurine chloramine inhibits proliferation of rheumatoid arthritis synoviocytes by triggering a p53-dependent pathway

    Taurine chloramine (Tau-Cl), originating from activated neutrophils, possesses antiinflammatory activities. Fibroblast-like synoviocytes (FLS) participate in the chronic synovitis and synovial membrane hyperpl...

    E. Kontny, W. Rudnicka, M. Chorąży-Massalska, J. Marcinkiewicz… in Inflammation Research (2006)

  8. No Access

    Article

    Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide

    Objective and Design: The myeloperoxidase system of neutrophils generates chlorinating and brominating oxidants in vivo. The major haloamines of the system are taurine chloramine (TauCl) and taurine bromamine (Ta...

    J. Marcinkiewicz, M. Mak, M. Bobek, R. Biedroń, A. Białecka… in Inflammation Research (2005)

  9. No Access

    Article

    Taurine chloramine and taurine bromamine induce heme oxygenase-1 in resting and LPS-stimulated J774.2 macrophages

    Taurine chloramine (TauCl) and taurine bromamine (TauBr) are products of activated neutrophils and eosinophils, respectively. It has been reported that TauCl, has strong anti-inflammatory properties. In a numb...

    R. Olszanecki, J. Marcinkiewicz in Amino Acids (2004)

  10. No Access

    Article

    Taurine chloramine modulates cytokine production by human peripheral blood mononuclear cells

     The effect of taurine (Tau) and taurine chloramine (Tau-Cl) on the production of TNF-α, IL-1β, and IL-6 by peripheral blood mononuclear cells of healthy volunteers was examined. Cells were stimulated with bacter...

    M. Chorąży, E. Kontny, J. Marcinkiewicz, W. Maśliński in Amino Acids (2002)

  11. No Access

    Article

    Effect of taurine chloramine, the product of activated neutrophils, on the development of collagen-induced arthritis in DBA 1/J mice

     Taurine chloramine (TauCl), a product of neutrophil myeloperoxidase – halide system, formed by a reaction of taurine with HOCl, is known as an anti-microbial and anti-inflammatory long-lived oxidant. We previ...

    B. Kwaśny-Krochin, M. Bobek, E. Kontny, P. Gluszko, R. Biedroń, B. M. Chain… in Amino Acids (2002)

  12. No Access

    Article

    Antimicrobial and cytotoxic activity of hypochlorous acid: interactions with taurine and nitrite

    Objective. HOCl, a major bactericidal product of neutrophil MPO - halide system reacts with taurine to form taurine chloramine (TauCl), a less toxic anti-inflammatory mediator. Recently, it has b...

    J. Marcinkiewicz, B. Chain, B. Nowak, A. Grabowska, K. Bryniarski… in Inflammation Research (2000)

  13. No Access

    Article

    Influence of no-donor (SIN-1) on functions of inflammatory cells

    NO-donor SIN-1 (0.01–1.0 mM) dose-dependently inhibited the basal and FMLP (30.0 mM)-stimulated release of beta-glucuronidase from rat peritoneal leukocytes and antigen-specific stimulation of Inter-leukin-2 prod...

    A. Dembińska-Kieć, A. Żmuda, J. Marcinkiewicz, H. Sinzinger… in Agents and Actions (1991)

  14. No Access

    Article

    Sur une propriété de la loi de Gauß

    J. Marcinkiewicz in Mathematische Zeitschrift (1939)