-
Article
Effect of acute and chronic ethanol administration on serotonin turnover in rat brain
In rats treated acutely and chronically with ethanol, brain serotonin (5-HT) turnover was determined by measuring in the same animals the rate of accumulation of 5-HT and the rate of decline of 5-hydroxyindole...
-
Chapter
Alcohol Induced Susceptibility to Hypoxic Liver Damage: Possible Role in the Pathogenesis of Alcoholic Liver Disease?
Previous studies in our laboratory (1–3), have indicated that the major rate limiting factor in ethanol metabolism in the intact liver cell is the rate of mitochondrial reoxidation to NAD+ of NADH produced in the...
-
Chapter
Reversal of Ethanol Tolerance and Cross-Tolerance to Pentobarbital in the Rat
Adult male Wistar rats were fed nutritionally adequate liquid diets providing 35% of the total calories as ethanol, while pair-fed controls received the corresponding diet with ethanol replaced by an equicalor...
-
Chapter
Cross-Tolerance between Ethanol and Morphine
Adult male Wistar rats were fed chronically a liquid diet providing 35% of the calories as ethanol (10–12 g/kg ethanol daily), while pair-fed controls received the corresponding diet with alcohol replaced by a...
-
Chapter
Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates
Previously it has been shown that chronic administration of p-chlorophenylalanine (p-CPA), slowed the development of tolerance to ethanol, pentobarbital and cross-tolerance development to ethanol in rats chronica...
-
Article
Effect of modification of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA) on ethanol tolerance
Rats were permanently depleted of brain dopamine (DA), serotonin (5-HT), 5-HT+norepinephrine (NE), or NE +DA by intraventricular injection of either 5,7-dihydroxytryptamine (5,7-DHT) or 6-hydroxydopamine (6-OH...
-
Article
Differential sensitivity to ethanol, pentobarbital, and barbital in spontaneously hypertensive and normotensive Wistar-Kyoto rats
Ethanol, pentobarbital, and barbital sleep times and blood levels on awakening were determined in female spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WK) rats. Ethanol-induced sleep times wer...
-
Article
Initial sensitivity versus acquired tolerance to ethanol in rats selectively bred for ethanol sensitivity
Chronic tolerance to ethanol-induced sleep, motor impairment (moving belt test), and hypothermia were examined in two lines of rats that had been selectively bred for their different initial sensitivities to e...
-
Article
Effect of raphe lesions on the development of chronic tolerance to pentobarbital and cross-tolerance to ethanol
Sham and electrolytic lesions of the dorsal, median, and median + dorsal raphe nuclei were made in different groups of rats, and the differential patterns of regional 5-HT depletion were verified chemically. O...
-
Article
Rapid and sensitive gas chromatographic method for detection of barbital and pentobarbital in blood using flash-heater methylation and nitrogen-specific detection
A sensitive and simplified method is described for the determination of barbital (B) and pentobarbital (PB) in blood using gas chromatography with a nitrogen-specific flame ionization detector. After a simple ...
-
Article
Role of Pavlovian conditioning in the development of tolerance and cross-tolerance to the hypothermic effect of ethanol and hydralazine
The role of Pavlovian conditioning in the development of tolerance to the hypothermic effect of ethanol and of cross-tolerance to hydralazine was investigated. In the first study, two groups of rats were treat...
-
Article
Roles of intoxicated practice in the development of ethanol tolerance
The development of tolerance to the motor impairment effect of ethanol was examined in separate groups of rats receiving and not receiving intoxicated practice. Tolerance to the motor impairment effect of etha...
-
Article
Relationship between initial sensitivity, acute tolerance and chronic tolerance to ethanol in a heterogeneous population of Swiss mice
Acute and chronic tolerance to ethanol hypothermia as a function of the initial sensitivity were examined in a heterogeneous population of Swiss mice. Based on their day 1 hypothermic response to a challenge d...
-
Article
Initial sensitivity, acute tolerance and alcohol consumption in fischer 344 and long evans rats
In separate groups of Fischer 344 and Long Evans rats, initial sensitivity and acute tolerance to ethanol were determined in a jum** test. Sensitivity measurements in each strain were carried out in separate...
