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Chapter
Comparison of HLA Phenotypes in Long-Term Survivors with Acute Lymphoblastic Leukemia Treated with Immunotherapy Versus Chemotherapy
Experimental data dealing with immunotherapy are usually obtained by studying pure inbred strains, in which all animals carry the same genetic pattern for immune response. In humans, it appears likely that any...
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Chapter
Antitumor Activity, Pharmacology, and Toxicity of Ellipticines, Ellipticinium, and 9-Hydroxy Derivatives: Preliminary Clinical Trials of 2-Methyl-9-Hydroxy Ellipticinium (NSC 264-137)
Ellipticine and some derivatives are highly cytotoxic substances which kill L1210 cells at concentrations ranging form 10-8 to 10-6 M. Some compounds in this series bind with high affinity to DNA (a...
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Chapter
First Results of a Randomized Trial on Immunotherapy of Head and Neck Tumors
Trials of active nonspecific immunotherapy as adjuvant therapy for tumors have increased dramatically in number since the results that have been published on acute leukemia [6] and melanoma [3, 5, 7–9]. In spi...
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Article
Results in children of acute lymphoid leukaemia protocol ICIG-ALL 9 consisting of chemotherapy for only nine months followed by active immunotherapy
Protocol ICIG-ALL 9 with only nine months' remission chemotherapy followed by active immunotherapy has given a proportion of about 50% of the patients on the plateau of the first remission curve, while 60% of ...
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Chapter
Results in Children of Acute Lymphoid Leukemia: Protocol ICIG-ALL 9 Consisting of Chemotherapy for Only 9 Months Followed by Active Immunotherapy
In 1962, we started a controlled study (the principle of which was based on our experimental data) [19] to compare active systemic immunotherapy (AI) with no treatment for patients with acute lymphoid leukemia...
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Article
1975 current results of the first 100 cytologically typed acute lymphoid leukemia submitted to BCG active immunotherapy
The first 100 acute lymphoid (and undifferentiated) leukemias, (of which the smears at the first presentation of the disease are still available for ty**), treated successively with remission induction chemo...
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Chapter
Combination of Adriamycine, VM 26, Cyclophosphamide & Prednisone (AVmCP) in Chemotherapy of Lympho & Reticulum Cell Sarcoma (Stages & Topographic Forms III & IV)
The treatment of lymphosarcoma and reticulosarcoma (LRS) has been influenced by two main factors :
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the development of new chemotherapy...
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Chapter
Comparison of the Combinations a) PDN + VCR°, b) PDN + VCR°→ADMx, c) PDN + VCR°→ADMx →CARx; and d) PDN + VCR + ASP° in Induction of First Remission of Acute Lymphoid Leukemia
Since the introduction of aminopterin 27 years ago, by Farber et al. (1948) (1), a dozen compounds have been made available to which the cells of acute lymphoid leukemia (ALL) are sensitive (see Mathé & Kenis,...
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Chapter
Potentiation of Drugs Using Sequential Chemotherapy Against Disseminated Breat, Bronchial and Central Nervous System Solid Tumors
The role of chemotherapy in the treatment of solid tumors remains imprecise, chemotherapy is only used when other treatments have been tried and have failed, such as surgery and/or radiotherapy. This limitatio...
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Chapter
Results Obtained in Our Adjuvant Screening Model with Corynebacterium parvum and Corynebacterium granulosum
Corynebacterium parvum and three preparations of Corynebacterium granulosum have been shown by one or several previous experiments to be able to stimulate immune responses. These agents were submi...
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Chapter and Conference Paper
Adriamycin in the Treatment of Acute Leukemias and Non-Hodgkin Lymphomas
This paper describes (1) the results of clinical trials of adriamycin given alone in the treatment of acute leukemias (1) and (2), the first results of giving adriamycin in combination with other drugs in the ...
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Chapter and Conference Paper
Nonspecific Immune Responses in Hematosarcomas and Acute Leukemias
Non-specific immune responses in cancer patients have been explored in several studies of both cell-mediated and humoral immunity [1, 2, 3, 4, 5, 6]. Since 1968 we have been systematically studying non-specifi...
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Chapter and Conference Paper
Attempts at Immunotherapy of 100 Acute Lymphoid Leukemia Patients: Some Factors Influencing Results
There is an extensive literature on experimental active immunoprevention of cancer, which is the stimulation of immune reactions before the establishment of the tumor. This stimulation can be specific, consisting...
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Chapter
Comparative Results Obtained in the Treatment of Acute Lymphoid Leukemia, Acute Myeloid Leukemia, and Acute Monocytoid Leukemia
Acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML) patients have been treated in our Institute according to different therapeutic principles (Fig. 1). In ALL we have tried to induce remission with che...
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Chapter and Conference Paper
Adriamycin in the Treatment of Acute Leukemias
This paper describes the results of our clinical trial of adriamycin in the treatment of acute leukemias, done after the first results of Bonadonna et al. [1]. A trial of this drug in solid tumors is at presen...
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Article
Attempts to prevent acquired immunological insufficiences in mice by Bacillus Calmette-Guérin
Le BCG donné avant une greffe de cellules leucémiques compatibles atténue l'effet immunodépresseur du développement de cette leucémie; il n'a aucun effet sur l'immunodépression due à un traitement ultérieur pa...
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Chapter
Active Immunotherapy by B.C.G.
Immunotherapy is a new method of killing malignant cells in the treatment of cancer. It is well known, from the rejection of incompatible grafts, that membrane antigens can excite an immune reaction capable of...
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Chapter and Conference Paper
Remission Induction with Poly IC in Patients with Acute Lymphoblastic Leukemia (Preliminary Results)
The oncostatic effect of polyinosinic-polycytidylic acid (poly IC) on several varieties of tumors has been reported previously (Levy et al., 1969) and we have observed its effect on Walker’s tumor. A number of cl...
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Chapter
Blastic Leukemia Complicating Reticulo-Sarcoma and Lympho-Sarcoma
A blastic leukaemia may appear in the course of a malignant lymphoma (Table 1): it is exceptional in Hodgkin’s disease, in follicular lymphoma, in reticulosarcoma, histiocytic type and in lymphosarcoma, lympho...
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Chapter
Five Years Experience of the Clinical Use of a Pathogen-Free Isolation Unit
Intensive chemotherapy and radiotherapy in current use in the treatment of malignant disease have given some outstanding results (Mathé et al., 1968) but they can cause, virtually inevitably, periods of profound ...
