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within J. D. Rothstein Remove this filter Medicine & Public Health Remove this filter

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  1. No Access

    Chapter

    Glutamate Transporter Dysfunction and Neuronal Death

    This chapter summarizes the normal function of the four major glutamate transporters in the mammalian central nervous system (CNS), as well as their structure, distribution, and cellular localization. We will ...

    R. Ganel, J. D. Rothstein in Ionotropic Glutamate Receptors in the CNS (1999)

  2. No Access

    Article

    The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine

    We show here that clozapine, a beneficial antipsychotic, down-regulates the expression of the glutamate transporter GLT-1 in the rat cerebral cortex, thereby reducing glutamate transport and raising extracellu...

    M Melone, L Vitellaro-Zuccarello, A Vallejo-Illarramendi… in Molecular Psychiatry (2001)

  3. No Access

    Chapter

    Regulation and Dysregulation of Glutamate Transporters

    Glutamate is the primary excitatory neurotransmitter in the central nervous system. During synaptic activity, glutamate is released into the synaptic cleft and binds to glutamate receptors on the pre- and post...

    R. Sattler, J. D. Rothstein in Neurotransmitter Transporters (2006)