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Chapter
Regulation and Dysregulation of Glutamate Transporters
Glutamate is the primary excitatory neurotransmitter in the central nervous system. During synaptic activity, glutamate is released into the synaptic cleft and binds to glutamate receptors on the pre- and post...
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Article
The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine
We show here that clozapine, a beneficial antipsychotic, down-regulates the expression of the glutamate transporter GLT-1 in the rat cerebral cortex, thereby reducing glutamate transport and raising extracellu...
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Chapter
Glutamate Transporter Dysfunction and Neuronal Death
This chapter summarizes the normal function of the four major glutamate transporters in the mammalian central nervous system (CNS), as well as their structure, distribution, and cellular localization. We will ...