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Article
Open AccessAdaption and validation of the Rwandese version of the Young Mania Rating Scale to measure the severity of a manic or hypomanic episode
Bipolar Disorder is one of the most incapacitating diseases among young persons, leading to cognitive and functional impairment and raised mortality, particularly death by suicide. Managing a manic episode and...
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Article
Open AccessGroup psychoeducation for persons with bipolar disorder in Rwanda: a study protocol for a randomized controlled trial
The efficacy of psychoeducation as an add-on treatment to pharmacotherapy is well documented in treating symptoms and in relapse prevention for persons with bipolar disorder in western countries. Yet, no studi...
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Article
Open AccessA genomic Neolithic time transect of hunter-farmer admixture in central Poland
Ancient DNA genome-wide analyses of Neolithic individuals from central and southern Europe indicate an overall population turnover pattern in which migrating farmers from Anatolia and the Near East largely rep...
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Article
Prognostic significance of YWHAZ expression in localized prostate cancer
Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic ...
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Article
Open AccessExtracting insights from the shape of complex data using topology
This paper applies topological methods to study complex high dimensional data sets by extracting shapes (patterns) and obtaining insights about them. Our method combines the best features of existing standard ...
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Article
MHC-mediated spatial distribution in brown trout (Salmo trutta) fry
Major histocompatibility complex (MHC) class I-linked microsatellite data and parental assignment data for a group of wild brown trout (Salmo trutta L.) provide evidence of closer spatial aggregation among fry sh...
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Article
Characterization of nine polymorphic microsatellite loci in Chorocaris sp. (Crustacea, Caridea, Alvinocarididae) from deep-sea hydrothermal vents
Species in the genus Chorocaris are caridean shrimp found at deep-sea hydrothermal vents at mid-ocean spreading centers. Nine unlinked polymorphic microsatellite loci were developed for this Chorocaris sp. 2 f...
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Chapter and Conference Paper
Fast Simulation of Quasistatic Rod Deformations for VR Applications
We present a model of flexible rods — based on Kirchhoff's geometrically exact theory — which is suitable for the fast simulation of quasistatic deformations within VR or functional DMU applications. Unlike simpl...
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Article
Erratum: The cost-effectiveness of candesartan-based antihypertensive treatment for the prevention of nonfatal stroke: results from the Study on COgnition and Prognosis in the Elderly
Correction to: Journal of Human Hypertension (2005) 19, 569–576. doi: 10.1038/sj.jhh.1001857 Published online 31 March 2005 Since the publication of the above-mentioned article, the authors have identified an ...
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Article
The cost-effectiveness of candesartan-based antihypertensive treatment for the prevention of nonfatal stroke: results from the Study on COgnition and Prognosis in the Elderly
Patients who survive a first stroke are often left with permanent disabilities, and have significant needs for rehabilitation and long-term care. Antihypertensive treatment reduces the risk of cardiovascular e...
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Article
Neck pain and disability following motor vehicle accidents—a cohort study
The primary aim of the study was to compare the prevalence of neck pain and disability in a group exposed to motor vehicle accidents (MVAs) with those in the general population. The secondary aim was to assess...
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Article
Preparation, radioiodination and in vitro evaluation of a nido-carborane-dextran conjugate, a potential residualizing label for tumor targeting proteins and peptides
Polysaccharides are not degradable by proteolytic enzymes in lysosomes and do not diffuse through cellular membranes. Thus, attached to an internalizing, targeting protein, such polysaccharide linkers, will re...
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Article
Open AccessHER2 expression in breast cancer primary tumours and corresponding metastases. Original data and literature review
The aim of this study was to evaluate whether the HER2 expression in breast cancer is retained in metastases. The HER2 expression in primary tumours and the corresponding lymph node metastases were evaluated i...
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Article
Kin-biased distribution in brown trout: an effect of redd location or kin recognition?
A wide range of animals have been reported to show kin-biased behaviours, such as reduced aggressiveness and increased food sharing among relatives. However, less is known about whether wild animals also assoc...
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Article
Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group
We have investigated a method for direct astatine labeling of proteins. Binding sites for astatine were created by coupling of a nido-carborane derivative to a protein, the human epidermal growth factor (hEGF), u...
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Article
Synkope in der präklinischen Notfallmedizin
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Article
A descriptive analysis of disorders in patients 17 years following motor vehicle accidents
Whiplash-associated disorders (WAD) are described and analysed 17 years after involvement in a motor vehicle accident. A self-report questionnaire was mailed to 121 patients registered at emergency department...
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Article
Antiarrhythmika in der Reanimationssituation
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Article
37-jährige Patientin mit Augenmuskellähmungen und rasch progredienter Ateminsuffizienz
Bei einer 37-jährigen Frau kam es zu einer progredienten okulobulbären Symptomatik mit Atemversagen und Tetraparese bei erhaltenem Bewusstsein. Ein zunächst vermutetes Miller-Fisher-Syndrom als Variante eines ...
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Chapter
SLT-Particles for Two-Step Targeting in Boron Neutron Capture Therapy
There are investigations proposing that liposomes, both stabilized and unstabilized, gather at sites of pathology, such as tumors, infections, and inflammations.1–4 The site-specific uptake of liposomal substance...
