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Introduction
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Article
Modeling the pharmacokinetics and pharmacodynamics of dexamethasone in depressed patients
Changes in time course effected by cortisol suppression and the relationship of these changes to the plasma dexamethasone concentration of suppressor and non-suppressor patients are described in this report on...
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Article
Holocene vegetation zonation in the eastern Sahara
Recent discoveries of fossil-bearing Holocene lake sediments from the eastern Sahara have brought further confirmation and detail to earlier indirect evidence that a major pluvial episode occurred between 9,5...
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Climate change and vegetation response
This study, as many other current investigations in palaeoecology is focused on the long-term dynamics of vegetation and the extent to which they are controlled by climate change. Climate and classes of climat...
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Sediment and pollen evidence for an early to mid-Holocene humid period in the eastern Sahara
A major problem in the study of Holocene palaeoenvironments of the arid and wind-deflated Sahara is the low preservation potential of sediments from which a record of past climatic change can be established. S...
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Article
Evidence from north-west Canada for an early Holocene Milankovitch thermal maximum
According to the Milankovitch theory of global climatic change, maximum summer solar radiation at high latitudes of the Northern Hemisphere occurred at 10,000 yr BP (refs 1, 2). In particular, it predicts summer ...
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Article
Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis
1. The 4-hydroxylation of debrisoquine was measured in 42 patients with chronic discoid psoriasis. 2. The proportion of poor metabolisers (4.8%) and the median metabolic ratio (0.5) in psoriatics were similar ...
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