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Chapter
GABAC Receptors: Structure, Function and Pharmacology
In the vertebrate central nervous system (CNS), γ-aminobutyric acid (GABA) is the most widely distributed neurotransmitter (Sivilotti and Nistri 1991). Initially, GABA was found to activate bicuculline-sensitive ...
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Chapter and Conference Paper
Active Decoupling of Dynamic Structure-Foundation Interactions
Telescopes are used to observe far-away objects. This requires a very high positioning accuracy. When installed on the ground, sometimes even the rotation of the earth must be accounted for to achieve a suffic...
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Chapter and Conference Paper
The Inhibitory Glycine Receptor: Structure-Function Studies on a Neuronal Chloride Channel
The glycine receptor (G1yR) is a ligand-gated chloride channel protein mediating synaptic inhibition in the vertebrate CNS. Molecular cloning of its a and ß subunit cDNAs has revealed homology of the G1yR to o...
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Article
Effect of atrial natriuretic factor (ANF) on nicotinic acetylcholine receptor channels in bovine chromaffin cells
Bovine chromaffin cells have binding sites for rat atrial natriuretic factor (ANF), as demonstrated autoradiographically by using the125I-labelled peptide. Patch-clamp recording revealed that ANF reduces acetylch...
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Article
Patch-clamp analysis of receptor-regulated ion channels
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Article
Molecular mechanisms underlying synaptic transmission
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Article
Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA
In the mammalian central nervous system, glycine and γ-aminobutyric acid (GABA) bind to specific and distinct receptors1–4 and cause an increase in membrane conductance to Cl− (refs 5–7). Neurones in various regi...
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Chapter and Conference Paper
Patch-Clamp Measurements of Elementary Chloride Currents Activated by the Putative Inhibitory Transmitters GABA and Glycine in Mammalian Spinal Neurons
Methods for measuring whole-cell and unitary Cl− currents in the soma membrane of cultured spinal cord neurons by the patch-clamp technique are described. To separate single channel Cl− currents activated by the ...
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Article
Single channel currents activated by glycine and GABA in spinal cord neurons