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Article
L’organisation française en réseau de soins pour la prise en charge des sarcomes
Les sarcomes sont des cancers rares et hétérogènes, dont la prise en charge est complexe et non optimale pour la majorité des patients. Les trois éléments clés de la prise en charge sont l’obtention d’un diagn...
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Article
Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs
Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma. Most of the data available on GISTs derive from retrospective studies of patients referred to oncology centers. The MolecGIST study so...
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Article
Aux origines de la maladie osseuse de Paget. Un nouveau cas néolithique dans le sud de la France
Parmi les ossements recueillis dans une grotte sépulcrale du sud de la France, nous avons reconnu un cas de maladie de Paget polyostotique. La datation C14, après calibration, donne un âge d’environ 3350 ans avan...
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Article
Open AccessHigh frequency of β-catenin heterozygous mutations in extra-abdominal fibromatosis: a potential molecular tool for disease management
Fibromatosis comprises distinct clinical entities, including sporadic extra-abdominal fibromatosis, which have a high tendency for recurrence, even after adequate resection. There are no known molecular biomar...
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Article
Open AccessPrognosis and predictive value of KIT exon 11 deletion in GISTs
KIT exon 11 mutations are observed in 60% of gastrointestinal stromal tumours (GIST). Exon 11 codes for residues Tyr568 and Tyr570, which play a major role in signal transduction and degradation of KIT. Our aim w...
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Article
Intérêt des banques de tumeurs virtuelles annotées dans les sarcomes : expérience et projet du Groupe Sarcome Français et du réseau européen Conticanet
Sarcomas are rare and various tumours likely to constitute an adequate model for collaborative studies of collected data and tumour samples. The French Sarcoma Group has created an “annotated virtual tumour ba...
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Article
Standards, Options et Recommandations 2006. Prise en charge des patients adultes atteints de sarcome des tissus mous, de sarcome utérin ou de tumeur stromale gastro-intestinale
La mise à jour des recommandations pour la pratique clinique (RPC) pour la prise en charge des patients atteints d’un sarcome des tissus mous a été élaborée par la Fédération nationale des centres de lutte con...
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Article
Chirurgie des sarcomes des tissus mous des membres et de la paroi du tronc
En 20 ans, le taux de contrôle local des sarcomes des tissus mous est passé d’environ 70 à 80 %, grâce entre autres aux progrès de la chirurgie. En dehors des centres spécialisés, la prise en charge des sarcom...
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Article
Tumeurs stromales du tube digestif (GIST)
Les tumeurs stromales du tube digestif (GIST) sont des tumeurs mésenshymateuses malignes rares, liées à une mutation fonctionnelle de c-kit ou de PDGFα. La prise en charge et le pronostic de ces tumeurs ont ét...
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Article
Intérêt et limites du grade histopronostique dans les sarcomes des tissus mous
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Article
Open AccessDNA topoisomerase IIα expression and the response to primary chemotherapy in breast cancer
The α isoform of Topoisomerase IIα (Topo IIα) is a proliferation marker as well as a target for several chemotherapeutic agents such as anthracyclines. In vitro studies have demonstrated the relationship between ...
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Article
Open AccessSummary of the Standards, Options and Recommendations for the management of patients with carcinoma of unknown primary site (2002)
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Article
pS2 protein: a marker improving prediction of response to neoadjuvant tamoxifen in post-menopausal breast cancer patients
Tamoxifen as sole initial therapy is gaining importance in the management of post-menopausal breast cancer patients. Age oestrogen (ER) and progesterone (PR) receptor status are accurately considered to select...
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Article
Variation of hormonal receptor, pS2, c-erbB-2 and GSTπ contents in breast carcinomas under tamoxifen: a study of 74 cases
Seventy-four post menopausal patients with primary non-metastatic invasive ductal carcinomas of the breast were first treated with tamoxifen alone (30 mg p.o. daily) for 5 months. To study changes induced by t...
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Article
Abstracts
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Chapter and Conference Paper
Involvement of Chromosome 12 in Well-Differentiated Liposarcoma
It is well known that “accurate classification of a given tumor is often not easy, so much that acknowledged international experts are still unable to pin a label on about 10% of sarcomas”(Fletcher 1990). In t...
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Chapter
Pathology and grading of soft tissue sarcomas
Soft tissue sarcomas (STS) can be defined as malignant tumors of nonepithelial extraskeletal tissue of the body exclusive of the reticuloendothelial system, glia, and supporting tissue of various parenchymal o...
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Article
Assessment of the experimental model of transplanted C6 glioblastoma in wistar rats
Establishing in vivo glioblastoma models from cell lines requires a very strict methodology, in order to obtain reproducible tumors presenting all the characteristics of human spontaneous glioblastomas. In this r...
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Chapter
Grading of Soft Tissue Sarcomas: Experience of the EORTC Soft Tissue and Bone Sarcoma Group
In oncology, the best possible information about prognosis is of paramount importance. This holds true particularly for clinical trials but also for determining the most appropriate treatment in general. Regar...