Neural Development and Regeneration
Cellular and Molecular Aspects
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Reference Work Entry In depth
Anti-Aging Strategies
There are age-associated motor and cognitive deficits, even in the absence of neurodegenerative disease, that result from alterations in the striatal dopamine or cholinergic systems, respectively. In both inst...
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Reference Work Entry In depth
Stress Response Signal Transduction
Trauma evokes a common response in all organ systems that includes early energy depletion followed by dysfunction of ionic gradients and triggering of stress response mechanisms with outcomes ranging from reco...
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Article
Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors
Keratinocyte growth factor (KGF) stimulates epithelial cell differentiation and proliferation, which are of major importance for wound healing. Local protein administration, however, has been shown to be ineff...
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Article
DNA Damage in Astrocytes Exposed to Fumonisin B1
Fumonisins are a group of toxic metabolites mainly produced by Fusarium moniliforme and Fusarium proliferatum, fungi that commonly occur on corn throughout the world. Fumonisin B1 (FB1), structurally resembling s...
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Chapter and Conference Paper
Hypoxia-lnduced DNA Damage in the Rat Brain
In the brain, the relationship between DNA damage, the capacity for DNA repair and neurological impairments in humans is poorly understood. Although DNA damage and compromised DNA repair in the brain have been...
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Article
Nitric Oxide Synthetase Activity in Cerebral Post-Ischemic Reperfusion and Effects of L-NG-Nitroarginine and 7-Nitroindazole on the Survival
Nitric Oxide (NO) mediates a series of physiological processes including regulation of vascular tone, macrophage-mediated cytotoxicity, platelet aggregation, learning and long-term potentiation, neuronal trans...
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Article
IGF-I gene transfer in thermally injured rats
Exogenous insulin-like growth factor-I (IGF-I) is known to improve the pathophysiology of a thermal injury, however, deleterious side-effects have limited its utility. Cholesterol-containing cationic liposomes...
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Article
Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications
We have systematically investigated the therapeutic potential of cationic liposome-mediated neurotrophic gene transfer for treatment of CNS injury. Following determination of optimal transfection conditions, w...
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Article
Effects of Glutathione Depletors on Post-Ischemic Reperfusion in Rat Brain
The present paper reports the effects of GSH depletion (diethylmaleate induced) on partial cerebral ischemia and reperfusion for 7 and 20 days. Our results confirm that there is a paradoxical protective effect...
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Chapter and Conference Paper
Neurotrophin binding to the p75 neurotrophin receptor is necessary but not sufficient to mediate NGF-effects on APP secretion in PC-12 cells
In the present study the pheochromocytoma cell line (PC-12) was used as a model system to determine the role of the two neurotrophin receptors in the regulation of amyloid precursor protein (APP) secretion by ...
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Article
Ornithine Decarboxylase Activity in Cerebral Post-Ischemic Reperfusion Damage: Effect of Methionine Sulfoximine
Excessive activation of glutamate receptors via the N-methyl-D-aspartate (NMDA) subtype appears to play a role in the sequence of cellular events which lead to irreversible ischemic damage to neurons. Furtherm...
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Article
Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion
Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological...
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Article
Free radical scavenger depletion in post-ischemic reperfusion brain damage
In the present study the influence of pretreatment with various GSH depletors such as buthionine sulfoximine (BSO) and diethylmaleate (DEM) was investigated in rats following cerebral postischemic reperfusion....
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Chapter and Conference Paper
Introduction
The now routine application of recombinant DNA techniques to developmental neurobiology has allowed for the precise determination of the molecular participants and processes involved in the regulation of gene ...
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Chapter and Conference Paper
Introduction
The hypothesis that growth factors and hormones determine or permit the expression of the phenotypic properties that characterize different neuroendocrine cell types has gained universal acceptance. Much of th...
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Book and Conference Proceedings
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Chapter and Conference Paper
Comparative Structural Features of Nerve Growth Factor and its Receptor
The nerve growth factor protein, NGF, is a subunit containing protein that plays a central role during developmental events associated with neuronal cell death, neurite extension and synapse formation in perip...
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Chapter and Conference Paper
Introduction
The research field of nervous system trauma has developed greatly in recent years for several reasons ranging, from advances in basic neurosciences to increasing clinical relevance due to the increasing number...
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Chapter and Conference Paper
Antioxidant Enzymatic Activities and Resistance to Oxidative Stress in Primary and Subcultured Rat Astroglial Cells
Aerobic metabolism produces potentially toxic oxygen species, such as superoxide anion radical, hydrogen peroxide and hydroxyl radical. Biochemical defences include both low molecular weight scavengers (α-toco...
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Chapter and Conference Paper
Introduction
Neuroimmunomodulation has its roots in work done in clinical psychology, where anecdotal clinical findings suggested that there were levels of interaction between the nervous system and the immune system that ...
