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  1. Article

    Open Access

    Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

    Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to intracellular stabilisation of hypoxia inducible f...

    S Carbajo-Pescador, R Ordoñez, M Benet, R Jover… in British Journal of Cancer (2013)

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  2. Article

    Open Access

    Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells

    Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells. However, the responsible pathways have not been clearly elucidated. A member of the forkhead transcrip...

    S Carbajo-Pescador, C Steinmetz, A Kashyap, S Lorenz… in British Journal of Cancer (2013)

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  3. No Access

    Article

    Physical and functional cooperation between AP-1 and β-catenin for the regulation of TCF-dependent genes

    Stabilization of cytoplasmic β-catenin is a hallmark of a variety of cancers. The stabilized β-catenin is able to translocate to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-re...

    K Toualbi, M C Güller, J-L Mauriz, C Labalette, M-A Buendia, A Mauviel… in Oncogene (2007)

  4. No Access

    Article

    Physical exercise and improvement of liver oxidative metabolism in the elderly

    Drug metabolizing capacity is generally reduced in the elderly, and physical exercise has been reported to increase drug oxidative metabolism. The purpose of this investigation was to study the effects of eng...

    J. L. Mauriz, B. Tabernero, J. García-López… in European Journal of Applied Physiology (2000)