105 Result(s)
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Article
Open AccessA disease-associated gene desert directs macrophage inflammation through ETS2
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug develop...
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Article
Surgical challenges of giant parathyroid adenomas weighing 10 g or more
An average parathyroid adenoma (PA) weighs < 1 g. This study aimed to characterise giant PAs ≥ 10 g (GPAs) to facilitate surgical management of primary hyperparathyroidism (PHPT).
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Article
Quercetin Protects Hepatocytes against CCl4-Induced Apoptosis via SIRT1 Regulation
Quercetin (Que) is a flavonoid compound found ubiquitously in nature with a variety of biological activities, including anti-apoptosis, anti-oxidant, free-radical scavenging, anti-inflammatory and anti-tumor e...
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Article
Open AccessManagement of colorectal anastomotic stricture with multidiameter balloon dilation: long-term results
Postoperative colorectal anastomotic strictures are quite common. As such, many techniques have been available to address such a problem, one of which is endoscopic dilation. The aim of the present study was t...
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Article
Analysis of the B cell receptor repertoire in six immune-mediated diseases
B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases. Each B cell expresses a single B cell receptor (BCR)1, and the diverse range of BCRs expressed by the total B cell pop...
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Article
The expression of P2Y14, a purinergic G-protein coupled receptor, defines functionally distinct subpopulations in placenta-derived hematopoietic stem progenitor cells
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Article
Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer
Colon cancer is the third leading cause of death from cancer worldwide with less than 10% survival rate at the late stage. Although mutations of certain genes have been implicated in familial colon cancer deve...
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Article
Smad4 in osteoblasts exerts a differential impact on HSC fate depending on osteoblast maturation stage
Osteoblasts (OBs) are indispensable for the maintenance of hematopoietic stem cells (HSCs) in the bone marrow microenvironment. Here we investigated how Smad4 modulates HSC fate at distinct stages of OB develo...
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Article
Decreased face primary motor cortex (face-M1) excitability induced by noxious stimulation of the rat molar tooth pulp is dependent on the functional integrity of medullary astrocytes
We have recently shown that application of the small-fiber excitant and inflammatory irritant mustard oil (MO) to the rat molar tooth pulp can decrease face-M1 excitability, but increase the excitability of t...
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Article
Network-analysis-guided synthesis of weisaconitine D and liljestrandinine
General strategies for the chemical synthesis of organic compounds, especially of architecturally complex natural products, are not easily identified. Here we present a method to establish a strategy for such ...
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Article
Open AccessTranscriptional repression of cancer stem cell marker CD133 by tumor suppressor p53
Novel therapeutic strategies are needed to overcome cancer recurrence, metastasis, and resistance to chemo- and radiotherapy. Cancer stem cells (CSCs) are major contributors to the malignant transformation of ...
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Article
Effects of three novel resistant black raspberry selections on Amphorophora agathonica feeding behavior and performance
Host plant resistance is a practical and cost-effective approach for growers to manage insect pests. Recently, three new sources of resistance in black raspberry (Rubus occidentalis; selections ORUS 3778-1, ORUS ...
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Article
Decreased face primary motor cortex (face-M1) excitability induced by noxious stimulation of the rat molar tooth pulp is dependent on the functional integrity of face-M1 astrocytes
Acute inflammatory dental pain is a prevalent condition often associated with limited jaw movements. Mustard oil (MO, a small-fiber excitant/inflammatory irritant) application to the rat molar tooth pulp induc...
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Chapter and Conference Paper
Data Analysis of Automated Monitoring System Based on Target Features
Automated monitoring system provides a potential technique for monitoring the indoor environment. Traditional automated monitoring systems are very expensive. This paper presents a cheap automated monitoring s...
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Article
Open AccessOverexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B
The chromosomal passenger complex (CPC) plays a pivotal role in controlling accurate chromosome segregation and cytokinesis during cell division. Aurora-B, one of the chromosomal passenger proteins, is importa...
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Chapter and Conference Paper
A Web-Based Interface for a System That Designs Sensor Networks
We describe the approach taken in the design of the interface for a system that helps application engineers who are not trained in computer science/engineering to design sensor networks. We cite various taxono...
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Article
Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells
The hypothesis of cancer stem cells has been proposed to explain the therapeutic failure in a variety of cancers including lung cancers. Previously, we demonstrated acquisition of epithelial–mesenchymal transi...
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Article
Treatment of autoimmune diabetes in NOD mice by Toll-like receptor 2 tolerance in conjunction with dipeptidyl peptidase 4 inhibition
We have shown that chronic administration of the Toll-like receptor 2 (TLR2) agonist Pam3CSK4 prevents diabetes in NOD mice by inducing TLR2 tolerance of dendritic cells (DCs). We have also reported that a novel ...
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Article
Dependence of the hall factor on the shape of the constant energy surfaces in n-type Si/SiGe quantum-well structures
The Hall factor in an n-type Si/SiGe two-dimensional structure is calculated for several growth directions and under different strain conditions. Contrary to the Hall factor for a circular constant energy surf...
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Article
Functional hybrid materials derived from natural cellulose
In this paper, we report a study on the optical and the electrical properties of pure cotton fibers (CF) from chemically surface- and morphology-modified samples coated with poly [2-methoxy-5-(2-ethylhexyloxy)...