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  1. Article

    Open Access

    Extraction of useful bioisostere replacments from the PDB

    T Ritschel, DJ Wood, J de Vlieg, M Wagener in Journal of Cheminformatics (2011)

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  2. Article

    Open Access

    Fleksy: a flexible approach to induced fit docking

    Markus Wagener, SB Nabuurs, J de Vlieg in Journal of Cheminformatics (2010)

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  3. No Access

    Chapter

    Engineering Surface Charges in a Subtilisin

    Introduction of multiple charged amino acid residues in the subtilisin Savinase by genetic engineering allowed us to modify the electrostatic properties of this enzyme in a systematic way. The effects of these...

    M. R. Egmond, W. P. Antheunisse, P. Ravestein, A. T. A. Mooren… in Subtilisin Enzymes (1996)

  4. No Access

    Chapter

    A Two-Dimensional NMR Study of the Complex of lac Repressor Headpiece with a 14 Base Pair lac Operator Fragment

    Lac repressor of E. coli recognizes a 20 to 25 basepair DNA sequence called the lac operator.1–4 When it binds to this region it blocks transcription of the genes coding for the lactose enzymes. Genetic and bioch...

    R. Boelens, R. M. Scheek, R. M. J. N. Lamerichs, J. de Vlieg… in DNA—Ligand Interactions (1987)