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Article
Vascular endothelial growth factor polymorphisms and clinical outcome in colorectal cancer patients treated with irinotecan-based chemotherapy and bevacizumab
The aim of the study was to evaluate the association of vascular endothelial growth factor (VEGF) genotypes with treatment efficacy in a randomized trial. This study compared two chemotherapy regimens (FOLFIRI ve...
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Article
Empirical therapy with ceftazidime combined with levofloxacin or once-daily amikacin for febrile neutropenia in patients with neoplasia: a prospective comparative study
Combination antimicrobial therapy represents common practice in the treatment of febrile neutropenia aiming to broaden the antimicrobial spectrum against Gram-negative pathogens. We did a prospective, non-rand...
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Article
Open AccessGemcitabine twice weekly as a radiosensitiser for the treatment of brain metastases in patients with carcinoma: a phase I study
Conventional treatment for brain metastases (BM) is whole-brain radiotherapy (WBRT). Efficacy is poor. It might be increased by a potent radiosensitiser such as gemcitabine which is believed to cross the disru...
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Article
Correction: Corrigendum: The genome sequence of Schizosaccharomyces pombe
Nature 415, 871–880 (2002). In this Article, the author Andreas Düsterhöft was mistakenly omitted: his name and affiliation (footnote 6) should have been inserted between M. Fuchs and C. Fritzc in the author l...
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Article
The genome sequence of Schizosaccharomyces pombe
We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between...
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Chapter and Conference Paper
A Preliminary Study of the Hemoglobin of Arenicola Marina
The extracellular hemoglobin of Arenicola marina, having a molecular weight of 3.9 MDa, consists of twelve identical subunits arranged in two superimposed hexagonal rings. Investigation of the molecule has reveal...