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Article
Open AccessInvolving research participants in a pan-European research initiative: the EPAD participant panel experience
Including participants in patient and public involvement activities is increasingly acknowledged as a key pillar of successful research activity. Such activities can influence recruitment and retention, as well a...
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Article
Open AccessEffect of project-based experiential learning on the health service delivery indicators: a quasi-experiment study
Kenya’s new constitution passed in 2010 recognizes the right of quality care resulting in the devolution of health service delivery to the sub-national units called counties in 2013. However, the health system...
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Article
Factors influencing consumption of fruits and vegetables in older adults in New Orleans, Louisiana
The objective of this study was to identify demographic, social and structural factors associated with intake of fruit and vegetables in older adults in New Orleans, Louisiana.
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Article
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans
The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African...
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Article
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53
Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present ...
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Article
Modeling and Simulation of a Donor Material Concept to Reduce Tool Wear in Friction Stir Welding of High-Strength Materials
This research proposes the “donor material” concept for reduction of tool's wear at the plunge phase by providing localized preheating at the plunge area using a softer material as a “donor.” This process gene...
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Article
Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants
We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing d...
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Article
Genome-wide association analysis of copy number variation in recurrent depressive disorder
Large, rare copy number variants (CNVs) have been implicated in a variety of psychiatric disorders, but the role of CNVs in recurrent depression is unclear. We performed a genome-wide analysis of large, rare C...
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Article
Bilateral synchronous rupture of the quadriceps tendon
Bilateral simultaneous rupture of the quadriceps tendon is a rare entity. They are often associated with degenerative changes of the tendons and predisposing conditions such as diabetes or excessive steroid us...
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Article
Depressive disorder moderates the effect of the FTO gene on body mass index
There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesi...
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Article
DNA vaccines to target the cancer testis antigen PASD1 in human multiple myeloma
We previously described PASD1 as a new cancer testis antigen in multiple myeloma (MM) that is retained post-therapy, suggesting the use of vaccination strategies to induce anti-PASD1 immunity in a setting of m...
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Article
Genome-wide association study of bipolar disorder in European American and African American individuals
To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n=1001 cases; n=1033 contr...
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Article
Singleton deletions throughout the genome increase risk of bipolar disorder
An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genom...
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Article
89Sr production in a reactor with solution fuel
The experimental results for the validation of a technology for producing 89Sr in a reactor with solution fuel are presented. The aggregate state of the fuel-a water solution of uranyl sulfate UO2SO4-opens up a u...
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Article
Assessment of variation in position of the leg during follow-up total hip replacement (THR) radiographs
Standardised radiographs post total hip replacement (THR) have been shown to be vitally important in the accurate assessment of stem migration. We aimed to review radiographs at our institution to assess the r...
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Article
Prospective randomized control trial comparing Biostop, a bioabsorbable cement restrictor with the standard Hardinge cement plug
This study is a randomized control trial comparing the effectiveness of Biostop, an absorbable cement restrictor with Hardinge, a nonabsorbable cement restrictor in 136 consecutive patients who had a Charnley ...
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TAOS: The Taiwanese-American Occultation Survey
The Taiwanese—American Occultation Survey (TAOS) seeks to determine the number and size spectrum for small (~ 3 km) bodies in the Kuiper Belt. This will be accomplished by searching for the brief occultations ...
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Article
TAOS: The Taiwanese–American Occultation Survey
The Taiwanese–American Occultation Survey (TAOS) seeks to determinethe number and size spectrum for small (∼3 km) bodies in the KuiperBelt. This will be accomplished by searching for the brief occultations of ...
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Article
Comparison of clips versus sutures for routine closure of orthopaedic wounds
We recommend the use of skin clips, using an assistant to evert the wound edges, as a routine form of wound closure in most orthopaedic procedures.
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Article
Determination of total platinum in plasma and plasma ultrafiltrate, from subjects dosed with the platinum-containing N-(2-hydroxypropyl)methacrylamide copolymer AP5280, by use of graphite-furnace Zeeman atomic-absorption spectrometry
AP5280 is an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer to which are linked tetrapeptide side chains containing bioactive platinum complexes at their C-terminal sides. We have developed and validated a ra...