19 Result(s)

Article

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo

A recent genome-wide association study identified the gene encoding lemur tyrosine kinase-2 (LMTK2) as a susceptibility gene for prostate cancer. The identified genetic alteration is within intron 9, but the mech...

C Manser, F Guillot, A Vagnoni, J Davies, K-F Lau, D M McLoughlin, K J De Vos… in Oncogene (2012)

Article

Fludarabine phosphate and melphalan: a reduced intensity conditioning regimen suitable for allogeneic transplantation that maintains the graft versus malignancy effect

Reduced intensity conditioning (RIC) for allogeneic stem cell transplantation allows stable donor cell engraftment with the maintenance of a graft versus malignancy effect. Many different regimens exist employ...

R K Dasgupta, S Rule, P Johnson, J Davies, A Burnett… in Bone Marrow Transplantation (2006)

Article

Anderson–Fabry disease: Clinical manifestations of disease in female heterozygotes

Anderson–Fabry disease is a rare, X-chromosomal lipid storage disorder caused by a deficiency of lysosomal α-galactosidase A. Clinical manifestations of Anderson–Fabry disease include excruciating pain in the ...

C. Whybra, Chr. Kampmann, I. Willers, J. Davies… in Journal of Inherited Metabolic Disease (2001)

Article

Dietary restraint and weight gain during pregnancy

Objectives: To explore dietary intake and weight gain during pregnancy in relation to dietary restraint.

R Conway, S Reddy, J Davies in European Journal of Clinical Nutrition (1999)

Chapter and Conference Paper

Successful Administration of the NO Synthase Inhibitor 546C88 as a Delayed Continuous Infusion in a Baboon Model of Septic Shock

Nitric oxide (NO) as both a vasodilator and under certain circumstances a cyto-toxic molecule is suggested as one of the critical mediators of severe sepsis and septic shock. Whether NO is really a central mol...

Günther Schlag, Heinz Redl, H. Gasser, Z. Khakpour… in Shock, Sepsis, and Organ Failure (1999)

Chapter

Glyceraldehyde and the Pancreatic β-Cell

D-glyceraldehyde is commonly used as a stimulus of insulin release from the pancreatic β-cell^1–3. It is generally accepted that the triose can be metabolized in the β-cell via the glycolytic pathway, thus stimula...

L. Best, A. C. Elliott, J. Davies in Physiology and Pathophysiology of the Isle… (1997)

Chapter

Morphological Changes in Adult Respiratory Distress Syndrome: Experimental and Clinical Data

Adult respiratory distress syndrome (ARDS) (Fig. 1) is the pulmonary manifestation of a diffuse microcirculatory injury that causes exudation of a protein-rich fluid into the pulmonary interstitium and alveola...

G. Schlag, H. Redl, W. Öhlinger, J. Davies in Pathophysiology of Shock, Sepsis, and Orga… (1993)

Chapter and Conference Paper

The Role of TNF in Gram-Negative Sepsis in Baboon

During sepsis TNF message is expressed and the protein is released both locally and into plasma. Teleologically such cytokine response must be beneficial to the host. However, from a certain threshold level of...

H. Redl, G. Schlag G, J. Davies, W. A. Buurman… in Shock, Sepsis, and Organ Failure (1993)

Chapter and Conference Paper

Trauma and Cytokines

Trauma still constitutes the most frequent cause of death in the first four decades of life and ranks third over all age brackets (Baker et al. 1980, Baue 1990, Chaudry et al. 1990, National Safety Council 198...

G. Schlag, H. Redl, S. Bahrami, J. Davies, P. Smuts… in Shock, Sepsis, and Organ Failure (1993)

Chapter

Live Escherichia coli Sepsis Models in Baboons

Sepsis and septic shock are usually complex conditions in which the overall picture heavily depends on numerous interrelationships among all organ systems and tissues. In the study of such a complicated proble...

G. Schlag, H. Redl, J. Davies… in Pathophysiology of Shock, Sepsis, and Orga… (1993)

Chapter

Activation/Adherence Phenomena of Leukocytes and Endothelial Cells in Trauma and Sepsis

Leukocytes, in particular polymorphonuclear neutrophils (PMNs), release important mediators of microvascular injury seen after ischemia/reperfusion, hemorrhage, and sepsis. Adherence of PMNs to the endothelium...

H. Redl, G. Schlag, R. Kneidinger… in Pathophysiology of Shock, Sepsis, and Orga… (1993)

Chapter

Bacterial Translocation During Traumatic Shock in Baboons

Bacterial translocation secondary to gut damage caused by traumatic shock is a source of posttraumatic sepsis. Enteral bacterial translocation has been implicated as a possible cause of the subsequent developm...

G. Schlag, H. Redl, J. Davies… in Pathophysiology of Shock, Sepsis, and Orga… (1993)

Chapter

Hypovolemic-Traumatic Shock Models in Baboons

Trauma and hemorrhage should closely mimic human polytrauma to create a valid basis for defin itive conclusions on the pathomechanisms and pathophysiology of polytrauma.

G. Schlag, H. Redl, Z. Khakpour, J. Davies… in Pathophysiology of Shock, Sepsis, and Orga… (1993)

Chapter

The Cytokine Network in Trauma and Sepsis I: TNF and IL-8

During infection and sepsis the genes for many cytokines are expressed and some of the proteins are also released both locally and into plasma. Teleologically, such cytokine response must be beneficial to the ...

H. Redl, G. Schlag, S. Bahrami, J. Davies… in Pathophysiology of Shock, Sepsis, and Orga… (1993)

Article

Vascular Surgery I

C. J. Ranaboldo, J. Davies, A. D. B. Chant… in Irish Journal of Medical Science (1992)

Chapter and Conference Paper

Bacterial Translocation in a Baboon Model of Hypovolemic-Traumatic Shock

Bacterial translocation secondary to gut damage caused by traumatic shock is a source of posttraumatic sepsis. In several series, only one third of multiorgan failure patients with clinical manifestations of s...

G. Schlag, H. Redl, H. P. Dinges, J. Davies, K. Radmore in Shock, Sepsis, and Organ Failure (1991)