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Article
Sequential Value of Information for Subsurface Exploration Drilling
Quantitative methods are needed for systematic decision-making during exploration for subsurface resources, but few methods exist that fully incorporate the interaction of geological, operational, and financia...
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Article
Efficacy of Information in Mineral Exploration Drilling
In mineral exploration, targets need to be confirmed by means of drilling. Such drilling is based on anomalies often detected in geochemical and/or geophysical exploration. Because drilling is costly and becau...
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Article
Open AccessDiagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel
Solitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow as...
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Article
Open AccessPrevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network
During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved treatment outcome. All of these novel substances differ at l...
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Article
Open AccessWhole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group
For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnost...
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Article
Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group
The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of an...
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Article
Imaging myeloma and related monoclonal plasma cell disorders using MRI, low-dose whole-body CT and FDG PET/CT
The identification of bone lesions and extramedullary disease is crucial in the diagnosis of myeloma. Whole-body X-ray (WBXR) is considered the gold standard for the detection of myeloma bone lesions. Neverth...
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Article
Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group
Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma characterized by the presence of circulating plasma cells. It is classified as either primary PCL occurring at diagnosis or as secondary P...
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Article
Open AccessAntitumour and antiangiogenic effects of Aplidin® in the 5TMM syngeneic models of multiple myeloma
Aplidin® is an antitumour drug, currently undergoing phase II evaluation in different haematological and solid tumours. In this study, we analysed the antimyeloma effects of Aplidin in the syngeneic 5T33MM model,...
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Article
Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells
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Article
Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients
The cell surface expression of CD9, a glycoprotein of the tetraspanin family influencing several processes including cell motility and metastasis, inversely correlates with progression in several solid tumors....
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Chapter and Conference Paper
Multiple-point geostatistics: a powerful tool to improve groundwater flow and transport predictions in multi-modal formations
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Article
Stochastic estimation of facies using ground penetrating radar data
Explicitly defining large-scale heterogeneity is a necessary step of groundwater model calibration if accurate estimates of flow and transport are to be made. In this work, neural networks are used to estimate...
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Article
Extreme value analysis of diamond-size distributions
Extreme value analysis provides a semiparametric method for analyzing the extreme long tails of skew distributions which may be observed when handling mining data. The estimation of important tail characterist.....