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Article
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity
Defects in pathways governing genomic fidelity have been linked to improved response to immune checkpoint blockade therapy (ICB). Pathogenic POLE/POLD1 mutations can cause hypermutation, yet how diverse mutations...
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Article
CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains
Insulators play a critical role in spatiotemporal gene regulation in animals. The evolutionarily conserved CCCTC-binding factor (CTCF) is required for insulator function in mammals, but not all of its binding ...
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Protocol
Proximity Ligation-Assisted ChIP-Seq (PLAC-Seq)
Proximity ligation-assisted ChIP-Seq (PLAC-Seq), also known as HiChIP, is a method to detect and quantify chromatin contacts anchored at genomic regions bound by specific proteins or histone modifications. By ...