-
Article
Open AccessChronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study was to assess the effect of moderate CKD on anxiety in rats...
-
Article
Open AccessThe kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia
We previously showed the anti-inflammatory effects of kynurenic acid (KYNA) and its brain-penetrable analog N-(2-(dimethylamino)ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2-carboxamide (SZR104) both in vivo a...
-
Article
Open AccessTransglutaminase 2 associated with PI3K and PTEN in a membrane-bound signalosome platform blunts cell death
Atypically expressed transglutaminase 2 (TG2) has been identified as a poor prognostic factor in a variety of cancers. In this study, we evaluated the contribution of TG2 to the prolonged cell survival of diff...
-
Article
Open AccessExtensive proteome and functional genomic profiling of variability between genetically identical human B-lymphoblastoid cells
In life-science research isogenic B-lymphoblastoid cell lines (LCLs) are widely known and preferred for their genetic stability – they are often used for studying mutations for example, where genetic stability...
-
Article
Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties
Mycobacterium vaccae (NCTC 11659) is an environmental saprophytic bacterium with anti-inflammatory, immunoregulatory, and stress resilience properties. Previous studies have shown that whole, heat-killed preparat...
-
Article
A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study
Kynurenic acid (KYNA) has well-established protective properties against glutamatergic neurotransmission, which plays an essential role in the activation and sensitization process during some primary headache ...
-
Article
Pre-treatment with new kynurenic acid amide dose-dependently prevents the nitroglycerine-induced neuronal activation and sensitization in cervical part of trigemino-cervical complex
The systemic administration of nitroglycerine induces attacks in migraineurs and is able to activate and sensitize the trigeminal system in animals involving glutamate and α7-nicotinic acetylcholine receptors,...
-
Article
Modifications on the carboxylic function of kynurenic acid
Pharmacological and histological studies of ten new amides of kynurenic acid revealed that N-(2-N,N-dimethylaminoethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride has effective neuroprotective properties. Nam...
-
Article
Behavioural studies with a newly developed neuroprotective KYNA-amide
The neuroactive properties and neuroprotective potential of endogenous l-kynurenine, kynurenic acid (KYNA) and its derivatives are well established. KYNA acts as an antagonist on the obligatory co-agonist glycine...
-
Article
Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington’s disease
Huntington’s disease (HD) is a progressive neurodegenerative disorder, the pathomechanism of which is not yet fully understood. Excitotoxicity is known to be involved in the development of HD and antiglutamate...
-
Article
HoxA3 is an apical regulator of haemogenic endothelium
In the develo** mouse embryo, a region of the dorsal aorta endothelium generates haematopoietic cells, but how the switch to endothelium or haematopoiesis is controlled has been unclear. HoxA3 induces endoth...
-
Article
CE Enantioseparation of Betti Bases with Cyclodextrins and Crown Ether as Chiral Selectors
Direct capillary zone electrophoretic methods were developed for the separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol and 2-(α-aminoarylmethyl)-1-naphthol analogues. The effects of selector and b...
-
Article
Comparison of Separation Performances of Cellulose-Based Chiral Stationary Phases in LC Enantioseparation of Aminonaphthol Analogues
The enantiomers of 1-(α-aminoarylmethyl)-2-naphthol, 1-(α-aminoalkyl)-2-naphthol and 2-(α-aminoarylmethyl)-1-naphthol analogues were separated on tris(3,5-dimethylphenyl)carbamoyl cellulose-based CelluCoat and...
-
Article
In vitro formation of selegiline-N-oxide as a metabolite of selegiline in human, hamster, mouse, rat, guinea-pig, rabbit and dog
It is well established in the litrature, that selegiline is metabolised to itsN-dealkylated metabolites,N-desmethylselegiline, methamphetamine and amphetamine. However, most studies on selegiline metabolism did n...
-
Article
Thein vitro biosynthesis and stability measurement with agyl-glycuronide isoformes of the main metabolite of ipriflavone
The formation and stability of 1-β-glucuronide conjugate of the main metabolite of ipriflavone [7-(1-carboxy-ethoxy)-isoflavone] (CI) — were studied by using liver microsomes, hepatocytes, and isolated perfuse...
-
Article
A Nonlinear Wave Metric and its CNN Implementation for Object Classification
In this paper a nonlinear wave metric is introduced for object classification. It is shown that the choice of a metric is a nontrivial problem since it is easy to give examples when well-known distance measure...
