7 Result(s)
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Article
Open AccessReal-world performance analysis of a novel computational method in the precision oncology of pediatric tumors
The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized...
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Open AccessCorrection to: Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors
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Article
Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma
The incidence of head and neck squamous cell carcinomas is still growing, and the long-term prognosis of advanced disease remains poor. Only a fraction of head and neck cancers are sensitive to the EGFR-inhibi...
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Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR)
The embryonal tumor with abundant neuropil and true rosettes is a rare and highly malignant variant of embryonal brain tumors. It usually affects infants and young children under the age of 4 years and exhibit...
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Open AccessMDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients
Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in...
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Article
Open AccessDecreased functional activity of multidrug resistance protein in primary colorectal cancer
The ATP-Binding Cassette (ABC)-transporter MultiDrug Resistance Protein 1 (MDR1) and Multidrug Resistance Related Protein 1 (MRP1) are expressed on the surface of enterocytes, which has led to the belief that ...
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Article
A specifically radiolabeled somatostatin analog with strong antitumor activity induces apoptosis and accumulates in the cytosol and the nucleus of HT29 human colon carcinoma cells
The new heptapeptide somatostatin analog TT-232 decreases proliferation of HT-29 human colon carcinoma cells in vitro by reducing mitotic and increasing apoptotic activity. We have synthesized and characterize...
