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Article
Open AccessReal-world performance analysis of a novel computational method in the precision oncology of pediatric tumors
The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized...
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Article
Open AccessCorrection to: Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors
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Article
Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma
The incidence of head and neck squamous cell carcinomas is still growing, and the long-term prognosis of advanced disease remains poor. Only a fraction of head and neck cancers are sensitive to the EGFR-inhibi...
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Article
Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR)
The embryonal tumor with abundant neuropil and true rosettes is a rare and highly malignant variant of embryonal brain tumors. It usually affects infants and young children under the age of 4 years and exhibit...
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Article
Open AccessMDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients
Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in...
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Article
Open AccessDecreased functional activity of multidrug resistance protein in primary colorectal cancer
The ATP-Binding Cassette (ABC)-transporter MultiDrug Resistance Protein 1 (MDR1) and Multidrug Resistance Related Protein 1 (MRP1) are expressed on the surface of enterocytes, which has led to the belief that ...
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Article
Molecular Profiling of Parathyroid Hyperplasia, Adenoma and Carcinoma
The objective of the study was to examine proliferation and apoptosis associated gene expression in the whole sequence parathyroid lesions to reveal specific features of carcinoma. This study was based on surg...
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Article
Integrating molecular diagnostics into anticancer drug discovery
Efforts to repeat the success of pioneering molecularly targeted cancer drugs, such as trastuzumab, for particular patient populations have been hampered by factors such as a lack of correlation between the mo...
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Apoptosis and cancer
Impaired molecular regulation of active (programmed) cell death is one of the most important hallmark of cancer. Apoptosis is the best characterized biochemical and morphological form of cell death, although o...
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Article
Molecular pathology of tumor metastasis III
Therapy of tumor progression and the metastatic disease is the biggest challenge of clinical oncology. Discovery of the diverse molecular pathways behind this complex disease outlined an approach to better tre...
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Article
A specifically radiolabeled somatostatin analog with strong antitumor activity induces apoptosis and accumulates in the cytosol and the nucleus of HT29 human colon carcinoma cells
The new heptapeptide somatostatin analog TT-232 decreases proliferation of HT-29 human colon carcinoma cells in vitro by reducing mitotic and increasing apoptotic activity. We have synthesized and characterize...
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Article
Regulation of differentiation, proliferation and drug-induced apoptosis in HT58 lymphoma cells
Recently, it has been suggested, that differentiated cells are more resistant to the apoptotic effect of DNA damaging agents possibly due to the decreased activity of “damage detecting/apoptosis triggering” me...
