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Article
Open AccessEye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure
Aqueous humor drainage is essential for the regulation of intraocular pressure (IOP), a major risk factor for glaucoma. The Schlemm’s canal and the non-conventional uveoscleral pathway are known to drain aqueo...
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Article
Open AccessThe tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma
Vascular endothelial (VE)-cadherin is an endothelial cell-specific protein responsible for endothelium integrity. Its adhesive properties are regulated by post-translational processing, such as tyrosine phosph...
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Article
Open AccessSoluble VE-cadherin in metastatic breast cancer: an independent prognostic factor for both progression-free survival and overall survival
Patients with metastatic breast cancer (MBC) represent a heterogeneous group, with large differences in outcomes from individual patients. VE-cadherin, an endothelial-specific cadherin, was shown to promote tu...
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Article
Towards a specific marker for acute bradykinin-mediated angioedema attacks: a literature review
Bradykinin-mediated angioedema (AE) is a rare disease characterised by recurrent angioedema linked to acquired (e.g. angiotensin converting enzyme inhibitor induced AE) or hereditary disorders (e.g. AE type I ...
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Article
Open AccessMicrotubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth
Structural microtubule associated proteins (MAPs) stabilize microtubules, a property that was thought to be essential for development, maintenance and function of neuronal circuits. However, deletion of the st...
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Chapter
Soluble Vascular Endothelial (VE)-Cadherin: Toward a Marker of Endothelial Dysfunction
Endothelial dysfunction is a hallmark for vascular diseases. It is often seen in patients with coronary artery disease, diabetes, hypertension, rheumatoid arthritis, systemic vasculitis, and cancer. Identifica...
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Article
Lack of Antitumor Activity of Recombinant Endostatin in a Human Neuroblastoma Xenograft Model
Patients with metastatic neuroblastoma are rarely curable with currently available therapy, and the search for new treatment options, which include the use of inhibitors of tumor angiogenesis, is warranted. He...
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Article
Derivatives of Di-O-octanoylglycerol and mono-O-octylglycerol as modulators of protein kinase C and diacylglycerol kinase activities
Twelve analogs of 1,2-di-O-octanoylglycerol modified at C-3 and three quaternaryN-alkyl-ammonium derivatives of glycerol were synthesized. The compounds were testedin vitro as potential modulators of the calcium ...
