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Article
Reverting to old theories of ageing with new evidence for the role of somatic mutations
With age, somatic mutations accumulate in the genome of healthy individuals, but the functional outcome of this increased mutational load has been unclear. Recent sequencing data support a functional role for ...
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Article
Artificial neural network (ANN) modelling for the estimation of soil microbial biomass in vineyard soils
Soil microbial biomass (SMB-C) is one of the most frequently used parameters for the assessment of soil quality, but no threshold values have ever been proposed. We challenged the problem of a reliable numeric...
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Article
Open AccessWhole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type
The lifelong accumulation of somatic mutations underlies age-related phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in a tissue-specific way. Whole genome analyses of so...
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Article
Open AccessSomatic mutagenesis in satellite cells associates with human skeletal muscle aging
Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident stem cells. To study the connection between SC aging...
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Article
Open AccessRare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time
Accumulation of progerin is believed to underlie the pathophysiology of Hutchinson-Gilford progeria syndrome, a disease characterized by clinical features suggestive of premature aging, including loss of subcu...
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Article
Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia
Phosphoinositide 3-kinase γ (PI3Kγ) is linked to neuroinflammation and phagocytosis. This study was conducted to elucidate conjectural differences of lipid kinase-dependent and kinase-independent functions of ...
