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Chapter and Conference Paper
Geometrical Analysis of Bursting Pacemaker Neurons Generated by Computational Models: Comparison to In Vitro Pre-Bötzinger Complex Bursting Neurons
Despite an incredible amount of progress toward understanding respiratory rhythm generation through the use of reduced mathematical models, controversy exists concerning the role of various ionic conductances ...
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Chapter and Conference Paper
Influence of 5-HT2A Receptor Blockade on Phrenic Nerve Discharge at Three Levels of Extracellular K+ in Arterially-Perfused Adult Rat
Recent observations from in vitro rodent preparations suggest an important role for the serotonin-2A (5-HT2A) receptor in eupneic (basal) and gas** respiratory activities, although the precise role appears to b...
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Chapter and Conference Paper
Upper Airway and Abdominal Motor Output During Sneezing: Is the In Vivo Decererate Rat an Adequate Model?
While numerous studies have focused on identifying and characterizing the neural mechanisms mediating upper airway defense reflexes in the anesthetized or decerebrate adult cat, little is known about these beh...
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Chapter and Conference Paper
Influence of Extracellular [K+]o on Inspiratory Network Complexity of Phrenic and Hypoglossal Nerve Discharge in Arterially-Perfused Adult Rat
Many in vitro mammalian preparations are used to study multiple aspects of central respiratory control. In these preparations, recordings of respiratory-related outputs that range from individual and populatio...
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Chapter
Burst-to-Burst Variability in Respiratory Timing, Inspiratory-Phase Spectral Activity, and Inspiratory Neural Network Complexity in Urethane-Anesthetized C57BL/6 Mice in vivo
Recent work from our laboratory has focused on identifying burst-to-burst variability in temporal and spectral characteristics for 5-minute time series segments of basal inspiratory motor discharges from ureth...
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Chapter
Respiratory Network Complexity in Neonatal Rat in vivo and in vitro
Numerous experimental preparations from neonatal rodents have been developed to study mechanisms responsible for respiratory rhythm generation. Amongst them, the in vivo anesthetized neonatal rat preparation and ...
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Chapter
Fast Oscillatory Rhythms in Inspiratory Motor Discharge: A Mathematical Model
In this paper, a mathematic model is applied to characterize spectral activity associated with fast oscillatory rhythms inherent in inspiratory discharges. Based on the estimated parameters, features are extra...
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Chapter
Glutamatergic Neurotransmission is Not Essential for, but Plays a Modulatory Role in, the Production of Gas** in Arterially-Perfused Adult Rat
Glutamatergic neurotransmission appears to be essential for generation of the eupneic pattern of inspiratory motor discharge as well as the expression of inspiratory-phase synchronization. The role of glutamat...
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Chapter
A Mathematical Model of pHi Regulation in Central CO2 - Chemoreception
In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pHi) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for t...
