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Article
Open AccessDistinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
Emerging evidence suggests that intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. However, the extent of heterogeneity within the villi stromal compartment and how I...
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Article
Open AccessYAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show...
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Article
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route of CSF drainage is still...
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Reference Work Entry In depth
Benefits and Pitfalls of Tumor Vessel Normalization
Tumor vasculature has been intensively studied not only to understand its role in tumor progression and metastasis but also to discover regulatory pro- and anti-angiogenic molecules and cells. Until now, numer...
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Protocol
Morphological Analysis of Lacteal Structure in the Small Intestine of Adult Mice
The lacteal is a blunt-ended lymphatic capillary located at the center of a villus in the small intestine that plays multifaceted roles under both physiologic and pathologic conditions. However, studies of its...
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Living Reference Work Entry In depth
Benefits and Pitfalls of Tumor Vessel Normalization
Tumor vasculature has been intensively studied not only to understand its role in tumor progression and metastasis but also to discover regulatory pro- and anti-angiogenic molecules and cells. Until now, numer...
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Article
Open AccessA Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner
Angiopoietin-1 (Ang1), a potential growth factor for therapeutic angiogenesis and vascular stabilization, is known to specifically cluster and activate Tie2 in high oligomeric forms, which is a unique and esse...
