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Article
Open AccessAging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T cells expressing low levels of IL-7 receptor alpha (IL-7Rαlow) and the presence of its ge...
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Article
Open AccessImplication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging
CD8+ T cells play an important role in host defense against infections and malignancies as well as contribute to the development of inflammatory disorders. Alterations in the frequency of naïve and memory CD8+ T ...
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Article
Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency
Immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines in primary antibody deficiencies (PADs) are largely unknown. We investigated antibody and CD4+ T-cell responses specific for SARS-CoV-2 spike ...
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Article
Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients
CD40 ligand (CD40L)-deficient patients display increased susceptibilities to infections that can be mitigated with effective prophylactic strategies including immunoglobulin G (IgG) replacement and prophylacti...
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Article
Open AccessCo-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer
Checkpoint inhibitors have demonstrated clinical impact in colorectal cancer with deficient mismatch repair and high microsatellite instability. However, the majority of patients have disease with stable micro...
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Article
Immunological and Clinical Phenoty** in Primary Antibody Deficiencies: a Growing Disease Spectrum
Although common variable immunodeficiency (CVID) is considered the most prevalent symptomatic primary antibody deficiency (PAD), there is a population with symptomatic PADs that do not meet criteria for CVID. ...
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Article
The immunobiology of MIF: function, genetics and prospects for precision medicine
The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by data showing that common functional polymorphisms in MIF are associated with disease susceptibility or clinical severity....
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Article
Open AccessInterleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial–Mesenchymal Transition
Precise mechanisms underlying interleukin-7 (IL-7)-mediated tumor invasion remain unclear. Thus, we investigated the role of IL-7 in tumor invasiveness using metastatic prostate cancer PC-3 cell line derivativ...
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Article
Open AccessPathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
T cells generate antigen-specific immune responses to their cognate antigen as a hallmark of adaptive immunity. Despite the importance of antigen-specific T cells, here we show that antigen non-related, bystan...
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Article
Open AccessAberrant expansion of CXCR5+ memory CD4 T cells in patients with systemic lupus erythematosus
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Characterization of Effector Memory CD8+ T Cells in the Synovial Fluid of Rheumatoid Arthritis
Little is known about the cellular characteristics of CD8+ T cells in rheumatoid arthritis (RA). We addressed this by investigating whether the frequency of the CD8+ T cell subsets and their phenotypic characteri...
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Article
Erratum to: Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
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Article
Open AccessDysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Interleukin (IL)-17 is a proinflammatory cytokine that is produced largely by a unique CD4+ T-helper (Th) subset called Th17 cells. The development of Th17 cells is suppressed by interferon (IFN)-γ produced by Th...
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Article
Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies
Monovariate and multivariate analyses including logistic regression were performed to determine associations among predicting variables [age, gender, immunofluorescence pattern, and anti-nuclear antibody (ANA)...
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Article
Resistance to Development of Collagen-Induced Arthritis in C57BL/6 Mice Is Due to a Defect in Secondary, but Not in Primary, Immune Response
Collagen-induced arthritis (CIA) is a rodent model of human rheumatoid arthritis. Mice of the H-2q (DBA/1J) background are highly susceptible to disease whereas mice of the H-2b (C57BL/6, B6) background are resis...
