9 Result(s)

Article

Aging gene signature of memory CD8⁺ T cells is associated with neurocognitive functioning in Alzheimer’s disease

Memory CD8⁺ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8⁺ T cells expressing low levels of IL-7 receptor alpha (IL-7Rα^low) and the presence of its ge...

Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young… in Immunity & Ageing (2023)

Article

Implication of IL-7 receptor alpha chain expression by CD8⁺ T cells and its signature in defining biomarkers in aging

CD8⁺ T cells play an important role in host defense against infections and malignancies as well as contribute to the development of inflammatory disorders. Alterations in the frequency of naïve and memory CD8⁺ T ...

Min Sun Shin, Hong-Jai Park, Juan Young, Insoo Kang in Immunity & Ageing (2022)

Article

Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency

Immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines in primary antibody deficiencies (PADs) are largely unknown. We investigated antibody and CD4⁺ T-cell responses specific for SARS-CoV-2 spike ...

Junghee Jenny Shin, Jennefer Par-Young, Serhan Unlu… in Journal of Clinical Immunology (2022)

Article

Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer

Checkpoint inhibitors have demonstrated clinical impact in colorectal cancer with deficient mismatch repair and high microsatellite instability. However, the majority of patients have disease with stable micro...

Ryan J. Slovak, Hong-Jai Park, William M. Kamp, Johannes M. Ludwig… in Scientific Reports (2021)

Article

Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial–Mesenchymal Transition

Precise mechanisms underlying interleukin-7 (IL-7)-mediated tumor invasion remain unclear. Thus, we investigated the role of IL-7 in tumor invasiveness using metastatic prostate cancer PC-3 cell line derivativ...

Min A. Seol, **-Hee Kim, Keunhee Oh, Gwanghun Kim, Myung Won Seo… in Scientific Reports (2019)

Article

Pathogenic function of bystander-activated memory-like CD4⁺ T cells in autoimmune encephalomyelitis

T cells generate antigen-specific immune responses to their cognate antigen as a hallmark of adaptive immunity. Despite the importance of antigen-specific T cells, here we show that antigen non-related, bystan...

Hong-Gyun Lee, Jae-Ung Lee, Do-Hyun Kim, Sangho Lim, Insoo Kang… in Nature Communications (2019)

Article

Aberrant expansion of CXCR5⁺ memory CD4 T cells in patients with systemic lupus erythematosus

**-Young Choi, Sang Taek Kim, Insoo Kang, Joe Craft in Arthritis Research & Therapy (2014)

Article

Erratum to: Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

Kamini Shah, Won-Woo Lee, Seung-Hyun Lee, Sang Hyun Kim… in Arthritis Research & Therapy (2010)

Article

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

Interleukin (IL)-17 is a proinflammatory cytokine that is produced largely by a unique CD4⁺ T-helper (Th) subset called Th17 cells. The development of Th17 cells is suppressed by interferon (IFN)-γ produced by Th...

Kamini Shah, Won-Woo Lee, Seung-Hyun Lee, Sang Hyun Kim… in Arthritis Research & Therapy (2010)