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Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation
DNA interstrand crosslinks (ICLs) are critical lesions for the mammalian cell since they affect both DNA strands and block transcription and replication. The repair of ICLs in the mammalian cell involves compo...
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Article
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11
The accumulation of DNA repair proteins at the sites of DNA damage can be visualized in mutagenized cells at the single cell level as discrete nuclear foci by immunofluorescent staining. Formation of nuclear f...