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Chapter and Conference Paper
Level-Aware Ecosystem Transformations for Industrial Lifecycle Interoperability
Interoperability between heterogeneous software ecosystems at increasing scale remains a major challenge. The automated translation of data between the data models and languages built around official or de fac...
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Chapter and Conference Paper
Multilevel Map** of Ecosystem Descriptions
One of the most significant challenges in information system design is the constant and increasing need to establish interoperability between heterogeneous software systems at increasing scale. Beyond individu...
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Chapter and Conference Paper
Ontology-Based Process Modelling for Design
The design process for large systems, e.g., industrial plants, involves large multi-disciplinary teams. Since each discipline has its own specialised concerns, the common thread is describing the functional re...
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Chapter and Conference Paper
A Conceptual Framework for Large-scale Ecosystem Interoperability
One of the most significant challenges in information system design is the constant and increasing need to establish interoperability between heterogeneous software systems at increasing scale. The automated t...
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Chapter and Conference Paper
Re-engineering the ISO 15926 Data Model: A Multi-level Metamodel Perspective
The ISO 15926 standard was developed to facilitate the integration of life-cycle data of process plants. The core of the standard is a highly generic and extensible data model trying to capture a holistic view...
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Chapter and Conference Paper
Enabling Information Interoperability through Multi-domain Modeling
Flexible integration of information systems with heterogeneous data structures and interfaces has been an important IT research goal for decades. It is a fundamental requirement for enterprise transformation t...
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Article
Open AccessEfficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme
Therapy options at the time of recurrence of glioblastoma multiforme are often limited. We investigated whether treatment with a new intratumoral thermotherapy procedure using magnetic nanoparticles improves s...
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Article
Modification of Aminosilanized Superparamagnetic Nanoparticles: Feasibility of Multimodal Detection Using 3T MRI, Small Animal PET, and Fluorescence Imaging
The aim of our study was to modify an aminosilane-coated superparamagnetic nanoparticle for cell labeling and subsequent multimodal imaging using magnetic resonance imaging (MRI), positron emission tomography ...
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Article
Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme
We aimed to evaluate the feasibility and tolerability of the newly developed thermotherapy using magnetic nanoparticles on recurrent glioblastoma multiforme. Fourteen patients received 3-dimensional image guid...
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Article
The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
Thermotherapy using magnetic nanoparticles is a new technique for interstitial hyperthermia and thermoablation based on magnetic field-induced excitation of biocompatible superparamagnetic nanoparticles. To ev...
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Chapter
Thermotherapy and Nanomedicine
Although nanoparticles have been already applied on patients in clinical trials, generally nanotechnology in medicine is regarded rather a vision than a realistic option. Progress in this field arises particul...
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Article
Increase of the Specific Absorption Rate (SAR) by Magnetic Fractionation of Magnetic Fluids
Magnetic fractionation was applied to a common magnetic fluid based on superparamagnetic iron-oxide nano-particles with core radius of 5nm. The fractions collected were investigated with respect to particle-si...
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Article
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11
The accumulation of DNA repair proteins at the sites of DNA damage can be visualized in mutagenized cells at the single cell level as discrete nuclear foci by immunofluorescent staining. Formation of nuclear f...
