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7 Result(s)
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Ikuo Kimura
Biomedicine
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Chapter
Free Fatty Acid Receptors and Their Role in Regulation of Energy Metabolism
The free fatty acid receptor (FFAR) is a G protein-coupled receptor (GPCR) activated by free fatty acids (FFAs), which play important roles not only as essential nutritional components but also as signaling mo...
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Living Reference Work Entry In depth
GPR41/FFAR3
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Book
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Chapter
Anti-Inflammatory and Insulin-Sensitizing Effects of Free Fatty Acid Receptors
Chronic low-grade inflammation in macrophages and adipose tissues can promote the development of obesity and type 2 diabetes. Free fatty acids (FFAs) have important roles in various tissues, acting as both ess...
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Reference Work Entry In depth
GPR41/FFAR3
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Article
Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance
Chronic morphine exposure upregulates adenylate cyclase signaling and reduces analgesic efficacy, a condition known as opioid tolerance. Nonopioid neurotransmitters can enhance morphine tolerance, but the mech...
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Article
Open AccessCommensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice
Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and it can progress to non-alcoholic steatohepatitis (NASH). Alterations in the gut microbiome have been implicated in th...
