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  1. No Access

    Article

    A differential molecular clock in enolase isoprotein evolution

    Ian N. M. Day, Mina Peshavaria, Gregory B. Quinn in Journal of Molecular Evolution (1993)

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    Protocol

    Microtiter Array Diagonal Gel Electrophoresis (MADGE) for Population Scale Genotype Analyses

    Human populations display enormous genetic variation, evident both at the phenotypic level and at the DNA level. These variations include both single “mutations” causative of profound disease and variations th...

    Ian N. M. Day, Manjeet Bolla, Lema Haddad… in Molecular Diagnosis of Genetic Diseases (1996)

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    Protocol

    High Throughput Modifications of Single-Strand Conformation Polymorphism Analysis

    In most patients with familial hypercholesterolemia (FH) the disorder is caused by a mutation in the gene coding for the low density lipoprotein receptor (LDL-R) (1). The variety of different defects observed in ...

    Steve E. Humphries, Vilmundur Gudnason… in Molecular Diagnosis of Genetic Diseases (1996)

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    Chapter

    Microplate Array Diagonal Gel Electrophoresis (MADGE) Methodologies: The First Five Years

    Recently, the Wellcome Trust (UK) and a consortium of major pharmaceutical companies have announced a 2-year initiative costing £28 million to identify 300, 000 and map 150, 000 human single nucleotide polymor...

    Ian N. M. Day, Emmanuel Spanakis… in Molecular Genetic Epidemiology — A Laborat… (2002)

  5. No Access

    Article

    MeltMADGE for mutation scanning of specific genes in population studies

    MeltMADGE reconfigures the mutation scanning process of denaturing gradient gel electrophoresis so that the independent variable is time rather than space and the dependent (denaturing) variable is temperature...

    Khalid K Alharbi, Mohammed A Aldahmesh, Tom R Gaunt, Hamid Rassoulian… in Nature Protocols (2010)