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  1. Article

    Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

    Nat. Genet. 42, 949–960 (2010); published online 10 October 2010; corrected after print 12 October 2011 In the version of this article initially published, there were errors in Table 1. Specifically, for eight...

    Iris M Heid, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi… in Nature Genetics (2011)

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    Article

    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of...

    Elizabeth K Speliotes, Cristen J Willer, Sonja I Berndt, Keri L Monda… in Nature Genetics (2010)

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    Article

    Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

    Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, s...

    Iris M Heid, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi… in Nature Genetics (2010)

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    Article

    MeltMADGE for mutation scanning of specific genes in population studies

    MeltMADGE reconfigures the mutation scanning process of denaturing gradient gel electrophoresis so that the independent variable is time rather than space and the dependent (denaturing) variable is temperature...

    Khalid K Alharbi, Mohammed A Aldahmesh, Tom R Gaunt, Hamid Rassoulian… in Nature Protocols (2010)

  5. Article

    Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Nat. Genet. 42, 105–116 (2010); published online 17 January 2010; corrected after print 26 March 2010 In the version of this article initially published, there were several errors in the author affiliations. T...

    Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena… in Nature Genetics (2010)

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    Article

    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly di...

    Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena… in Nature Genetics (2010)

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    Article

    Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease

    The human growth hormone gene (GH1) and the insulin-like growth factor 1 and 2 genes (IGF1 and IGF2) encode the central elements of a key pathway influencing growth in humans. This “growth pathway” also includes ...

    Santiago Rodriguez, Tom R. Gaunt, Ian N. M. Day in Human Genetics (2007)

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    Article

    Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK

    Evidence from rodents and association analyses in humans suggest the presence on chromosome Y of one or more genes affecting blood pressure (BP). The HindIII centromeric alphoid polymorphism has been reported to ...

    Santiago Rodríguez, **ao-he Chen, George J. Miller, Ian N. M. Day in Human Genetics (2005)

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    Chapter

    Microplate Array Diagonal Gel Electrophoresis (MADGE) Methodologies: The First Five Years

    Recently, the Wellcome Trust (UK) and a consortium of major pharmaceutical companies have announced a 2-year initiative costing £28 million to identify 300, 000 and map 150, 000 human single nucleotide polymor...

    Ian N. M. Day, Emmanuel Spanakis… in Molecular Genetic Epidemiology — A Laborat… (2002)

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    Article

    Analysis of low density lipoprotein receptor gene mutations and microsatellite haplotypes in Greek FH heterozygous children: six independent ancestors account for 60% of probands

    This study reports the characterization of 60% of low density lipoprotein receptor (LDLR) gene mutations in 150unrelated Greek familial hypercholes-terolaemia (FH) heterozygous children by the analysis of six...

    Joanne Traeger-Synodinos, Nicholas Mavroidis, E. Kanavakis… in Human Genetics (1998)

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    Protocol

    Microtiter Array Diagonal Gel Electrophoresis (MADGE) for Population Scale Genotype Analyses

    Human populations display enormous genetic variation, evident both at the phenotypic level and at the DNA level. These variations include both single “mutations” causative of profound disease and variations th...

    Ian N. M. Day, Manjeet Bolla, Lema Haddad… in Molecular Diagnosis of Genetic Diseases (1996)

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    Protocol

    High Throughput Modifications of Single-Strand Conformation Polymorphism Analysis

    In most patients with familial hypercholesterolemia (FH) the disorder is caused by a mutation in the gene coding for the low density lipoprotein receptor (LDL-R) (1). The variety of different defects observed in ...

    Steve E. Humphries, Vilmundur Gudnason… in Molecular Diagnosis of Genetic Diseases (1996)

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    Article

    A differential molecular clock in enolase isoprotein evolution

    Ian N. M. Day, Mina Peshavaria, Gregory B. Quinn in Journal of Molecular Evolution (1993)