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  1. No Access

    Article

    Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

    Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for ...

    Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick… in Nature Reviews Drug Discovery (2020)

  2. Article

    Open Access

    Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

    The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such a...

    Ian M. Copple, Wouter den Hollander, Giulia Callegaro… in Archives of Toxicology (2019)

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