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Article
Open AccessTitle: β3 Adrenergic Receptor Signaling in the Human Myometrium
Preterm labor leading to preterm birth is the leading cause of infant morbidity and mortality. Although β2 adrenergic agonists fail to provide adequate tocolysis, the expression of the β3 adrenergic receptor i...
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Article
Open AccessS-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor
Tocolytics show limited efficacy to prevent preterm delivery. In uterine smooth muscle cGMP accumulation following addition of nitric oxide (NO) has little effect on relaxation suggesting a role for protein S-...
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Article
A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction
Rates of premature birth are alarming and threaten societies and healthcare systems worldwide. Premature labor results in premature birth in over 50% of cases. Preterm birth accounts for three-quarters of infa...
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Protocol
Measurement of Phosphoinositols and Phosphoinositides Using Radio High-Performance Liquid Chromatography Flow Detection
Individual phosphoinositols and phosphoinositides in tissues and cells are commonly analyzed by thin-layer chromatography (TLC), liquid chromatography, and high-performance liquid chromatography (HPLC) after l...
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Chapter
On the Origin of Extracellular ATP in Cardiac Blood Vessels: A Dual Role for Endothelium
The exact mechanisms underlying the moment-to-moment regulation of blood flow in the heart by local mediators are not fully understood but appear to involve purines and their metabolites [1], specifically ATP,...
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Chapter
Compartmentation of Hormone Action in Adult Mammalian Cardiomyocytes
Our interests in hormone action on mammalian heart have led us to explore the hormonal responsiveness of purified adult ventricular cardiomyocytes. In this report, we shall describe cardiomyocytes from both ra...
