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Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer’s disease
Aside from APOE, the genetic factors that influence the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) remain largely unknown. We assessed whether a genetic risk score (GRS), based o...
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Erratum: Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease
Correction to: Molecular Psychiatry advance online publication, 20 March 2012; doi: 10.1038/mp.2012.14 Following the online publication of this article, the authors noted an error in Dr Caffarra's name. The co...
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Open AccessGenome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease
Recently, several genome-wide association studies (GWASs) have led to the discovery of nine new loci of genetic susceptibility in Alzheimer's disease (AD). However, the landscape of the AD genetic susceptibili...
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Article
Carbon isotopes in otolith amino acids identify residency of juvenile snapper (Family: Lutjanidae) in coastal nurseries
This study explored the potential for otolith geochemistry in snapper (Family: Lutjanidae) to identify residency in juvenile nursery habitats with distinctive carbon isotope values. Conventional bulk otolith a...
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APOE and Alzheimer disease: a major gene with semi-dominant inheritance
Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD LTR in 7351 cas...
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Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer’s disease risk
A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer’s disease (AD). Estrogen could protect the brain from neurodegeneration by augme...
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Genetic interaction between two apolipoprotein E receptors increases Alzheimer's disease risk
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Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE ε4 allele
Cholesterol regulates the production of amyloid beta (Aβ), which is central to the pathogenesis of Alzheimer's disease (AD), with high cellular cholesterol promoting and low cellular cholesterol reducing Aβ in...
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Article
The chemoattraction of lymphocytes by rheumatoid arthritis – synovial fluid is not dependent on the chemokine receptor CCR5
The objective was to study the potential role of the chemokine receptor CCR5 in the chemoattraction of lymphocytes by rheumatoid arthritis synovial fluid (RA-SF).
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Acute/Chronic respiratory failure III
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Antibodies to extractable cellular antigens in Spanish systemic lupus erythematosus (SLE) patients
We studied the frequency of antibodies to extractable cellular antigens in 90 Spanish SLE patients. Antibodies to Sm, nRNP, Ro and La were found, respectively, in 6 (6.6%), 18 (20%), 30 (33.3%) and 6 (6.6%) pa...