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  1. No Access

    Article

    Clinical impact of hyperattenuation of adrenal glands on contrast-enhanced computed tomography of polytraumatised patients

    To evaluate the prognostic value of hyperattenuating adrenal glands on contrast-enhanced CT of polytraumatised patients.

    J. Schek, S. Macht, J. Klasen-Sansone, P. Heusch, P. Kröpil, I. Witte… in European Radiology (2014)

  2. Article

    PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death

    To achieve malignancy, cancer cells convert numerous signaling pathways, with evasion from cell death being a characteristic hallmark. The cell death machinery represents an anti-cancer target demanding consta...

    E-M Schweikert, A Devarajan, I Witte, P Wilgenbus, J Amort… in Cell Death & Differentiation (2012)

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  3. Article

    Open Access

    Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells

    Major contributors to atherosclerosis are oxidative damage and endoplasmic reticulum (ER) stress-induced apoptosis; both of which can be diminished by the anti-oxidative protein paraoxonase-2 (PON2). ER stress...

    I Witte, S Altenhöfer, P Wilgenbus, J Amort, A M Clement, A Pautz… in Cell Death & Disease (2011)

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  4. No Access

    Chapter and Conference Paper

    Poster

    Increasing ethical, commercial and scientific needs as well as public pressure have initiated worldwide activities to elaborate reliable in vitro alternatives to animal toxicity testing procedures. In the last tw...

    Gerhard Gstraunthaler, Dieter Steinmassl… in Möglichkeiten und Grenzen der Reduktion vo… (1992)

  5. No Access

    Article

    Comparison of the cytotoxicity and DNA-damaging properties of 2,4-D and U 46 D Fluid (dimethylammonium salt of 2,4-D)

    U 46 D Fluid (the dimethylammonium salt of 2,4-dichlorophenoxyacetic acid in a commercial formulation) was more toxic to human fibroblasts than 2,4-dichlorophenoxyacetic acid (2,4-D). Moreover, U 46 D Fluid in...

    M. Clausen, G. Leier, I. Witte in Archives of Toxicology (1990)

  6. No Access

    Article

    Metabolism of pentachlorophenol to tetrachlorohydroquinone by human liver homogenate

    U. Juhl, I. Witte, W. Butte in Bulletin of Environmental Contamination and Toxicology (1985)

  7. No Access

    Article

    Correlation of the colony-forming abilities of xeroderma pigmentosum fibroblasts with repair-specific DNA incision reactions catalyzed by cell-free extracts

    Several normal and XP group A fibroblast cell lines were exposed to the weakly carcinogenic and toxic agent methyl methanesulfonate, and the differences in their abilities to form colonies were determined. The...

    H. W. Thielmann, I. Witte in Archives of Toxicology (1980)

  8. No Access

    Article

    On the biochemical mechanism of tumorigenesis in mouse skin

    Mice were treated on their back skin with a single promoting dose of the tritium labelled phorbol ester A 1 (TPA-20-3H) in the standard manner. Methods were investigated for determination of the fate and distribu...

    G. Kereibich, I. Witte, E. Hecker in Zeitschrift für Krebsforschung und Klinische Onkologie (1971)

  9. No Access

    Chapter

    On the Biochemical Mechanism of Tumorigenesis in Mouse Skin

    Mice were treated on their back skin with a single promoting dose of the tritium labelled phorbol ester A l (TPA-20-3H) in the standard manner Methods were investigated for determination of the fate a...

    Dr. G. Kreibich, I. Witte… in Zeitschrift für Krebsforschung und klinisc… (1971)