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  1. Article

    Open Access

    ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS)

    Neoadjuvant therapy is increasingly the standard of care in the management of locally advanced adenocarcinoma of the oesophagus and junction (AEG). In randomised controlled trials (RCTs), the MAGIC regimen of ...

    JV Reynolds, SR Preston, B O’Neill, L Baeksgaard, SM Griffin, C Mariette… in BMC Cancer (2017)

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  2. Article

    Open Access

    Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin

    Huntington’s disease (HD), a progressive neurodegenerative disease, is caused by an expanded CAG triplet repeat producing a mutant huntingtin protein (mHTT) with a polyglutamine-repeat expansion. Onset of symp...

    Z Tan, W Dai, T G M van Erp, J Overman, A Demuro, M A Digman… in Molecular Psychiatry (2015)

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  3. Article

    Open Access

    Shared functional defect in IP3R-mediated calcium signaling in diverse monogenic autism syndromes

    Autism spectrum disorder (ASD) affects 2% of children, and is characterized by impaired social and communication skills together with repetitive, stereotypic behavior. The pathophysiology of ASD is complex due...

    G Schmunk, B J Boubion, I F Smith, I Parker, J J Gargus in Translational Psychiatry (2015)

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  4. No Access

    Article

    Cocaine-sensitive O-methylation of noradrenaline in dental pulp of the rabbit: Comparison with the rabbit ear artery

    Incisor pulp from the rabbit metabolises exogenous noradrenaline in concentrations between 0.12 and 1.2 μmol/l mainly to NMN.

    D. A. S. Parker, I. S. de la Lande… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1987)

  5. No Access

    Article

    Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes

    Sodium channels and receptors to serotonin and kainate were ‘transplanted’ from human brain into frog oocytes, by isolating messenger RNA from a fetal brain, and injecting it into Xenopus laevis oocytes. The m...

    C. B. Gundersen, R. Miledi, I. Parker in Nature (1984)

  6. No Access

    Article

    Calcium transients in a crustacean motoneuron soma: Detection with arsenazo III

    Long lasting action potentials can be triggered in crayfish giant motor neurons by a short depolarizing pulse under different conditions. The concomitant increase in absorbance of the Ca indicator arsenazo III...

    G. Czternasty, M. Thieffry, I. Parker in Experientia (1984)

  7. No Access

    Chapter

    Experimental Approaches Used to Examine Single Glutamate-Receptor Ion Channels in Locust Muscle Fibers

    Fluctuation analysis has allowed estimation of the mean parameters of synaptic channels at vertebrate (Katz and Miledi, 1972, 1973) and invertebrate nerve-muscle junctions (Crawford and McBurney, 1976; Anderson e...

    S. G. Cull-Candy, I. Parker in Single-Channel Recording (1983)

  8. No Access

    Article

    Rapid kinetics of single glutamate-receptor channels

    Drug-induced ionic channels are known to operate by opening briefly when agonist molecules bind to receptor sites1–7 to produce rectangular current pulses, the amplitude and lifetime of which can be derived from ...

    S. G. Cull-Candy, I. Parker in Nature (1982)

  9. No Access

    Article

    Globin gene expression in MSV-transformed fibroblasts

    The activation of globin gene expression on viral transformation of 3T3 cells was investigated. Globin mRNA was determined using a radioactive complementary DNA probe. No difference was found between 3T3 and t...

    I. Parker, W. Fitschen in Experientia (1979)

  10. No Access

    Article

    Transition temperature of excitation–contraction coupling in frog twitch muscle fibres

    THE mechanism by which depolarisation of the muscle fibre membrane leads to release of stored Ca2+ ions from the sarcoplasmic reticulum, although crucial, is perhaps the least understood stage in excitation–contr...

    R. MILEDI, I. PARKER, G. SCHALOW in Nature (1979)

  11. No Access

    Article

    Calcium conductance of acetylcholine-induced endplate channels

    SEVERAL lines of evidence indicate that an influx of Ca2+ ions accompanies transmitter activation of the postsynaptic membrane at the neuromuscular junction1–5. We report here that we have now investigated the el...

    P. D. BREGESTOVSKI, R. MILEDI, I. PARKER in Nature (1979)

  12. No Access

    Article

    Birefringence signals and calcium transients in skeletal muscle

    TWITCHES in skeletal muscle are preceded and accompanied by changes in optical properties of the muscle fibres1–11. Measurements of birefringence give large signals which can be separated into two main components

    G. SUAREZ-KURTZ, I. PARKER in Nature (1977)

  13. No Access

    Article

    Calcium transients in frog slow muscle fibres

    MANY muscles in the frog contain slow as well as twitch muscle fibres, which differ in their innervation, electrical and contractile properties and fine structure1. Slow fibres give graded slow contractions with ...

    R. MILEDI, I. PARKER, G. SCHALOW in Nature (1977)

  14. No Access

    Article

    Observations on centromeric heterochromatin and satellite DNA in salamanders of the genus Plethodon

    DNA from Plethodon cinereus cinereus separates into two fractions on centrifugation to equilibrium in neutral CsCl. The smaller of these fractions has been described as a high-density satellite. It represents abo...

    H. C. Macgregor, Heather Horner, C. A. Owen, I. Parker in Chromosoma (1973)