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Article
Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice
Cynanchum wilfordii and Humulus lupulus L. have been used for their various pharmacological properties in South Korea as a traditional medicine or health functional food, respectively, and their intake may reliev...
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Article
Application of therapeutic protein-based fusion toxins
Protein-based therapeutics have been applied for decades to remove most malignant tumors. Many anti-tumor drugs using antibodies have been developed and put to practical use. However, due to limitations of ant...
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Article
Profiling of miRNA expression in mice kidney with diabetic nephropathy
Diabetic nephropathy (DN) is one of the complications of diabetes mellitus (DM) and the worldwide prevalence of DN has continued to increase. DN causes cellular stress and inflammation, which induces death of ...
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Article
Integrated analysis of miRNA and mRNA expression profiles in human endothelial cells exposed to fisetin
MicroRNAs (miRNAs) play vital regulatory roles in various biological processes including cell differentiation, proliferation and apoptosis. Several studies have examined the expression profiles of miRNAs in re...
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Article
Effect of crotonaldehyde on the induction of COX-2 expression in human endothelial cells
Cyclooxygenase-2 (COX-2), an inducible isoform protein, regulates diverse biological actions in vascular pathophysiology. COX-2 is induced in response to numerous stimuli, which results in prostaglandin (PG) p...
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Article
Integrated miRNA and mRNA expression profiling in response to eriodictyol in human endothelial cells
Eriodictyol, a flavonoid commonly found in citrus fruits, shows neurotrophic, antioxidant, anti- inflammatory, and anti-cancer effects under diverse pathophysiological conditions such as vascular diseases. In ...
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Article
Effect of crotonaldehyde on the induction of HO-1 expression in A549 cells
Cigarette smoke contains approximately 5,000 chemical components, including reactive chemicals and free radicals that are associated with an increased risk of chronic obstructive pulmonary disease (COPD). Ciga...
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Article
Profiling of gene expression using microarray in acrolein-treated human pulmonary fibroblasts
Pulmonary fibroblasts are essential for the integrity of alveolar structures and to restore lung tissue after injury. They are also important for inflammatory responses through their ability to attract leukocy...
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Article
Identification and characterization of MicroRNAs in acrolein-stimulated endothelial cells: Implications for vascular disease
MicroRNAs (miRNAs) have been implicated in the regulation of physiological and pathophysiological processes such as vascular disease. Analysis of miRNA expression profiles in vascular disease provides new insi...
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Article
Integrated analysis of miRNA and mRNA reveals that acrolein modulates GPI anchor biosynthesis in human primary endothelial cells
Acrolein (ACR) is a highly reactive α, β-unsaturated carbonyl compound that is related to several diabetic vascular complications. ACR, a ubiquitous aldehyde pollutant, is a product of incomplete combustion re...
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Article
The expression profile and function of Satb2 in zebrafish embryonic development
The present study shows the expression profile and function of the homeobox gene, satb2 during zebrafish embryonic development. Satb2 was ubiquitously expressed from the 1 cell stage to the 10-somite stage in zeb...
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Article
Induction of heme oxygenase-1 by acrolein mediates a cytoprotective effect in HepG2 cells
Acrolein is an alpha, beta-unsaturated aldehyde present in cigarette smoke, and is also a product of lipid peroxidation. Heme oxygenase-1 (HO-1) plays critical roles in preventing oxidative stress and other ce...
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Article
Uncaria rhynchophylla induces heme oxygenase-1 as a cytoprotective effect in RAW 264.7 macrophages
Uncaria rhynchophylla (UR) is an herbal plant that has been used widely to treat stroke, hypertension and atherosclerosis. Upregulated heme oxygenase-1 (HO-1) plays a crucial role in cytoprotection and anti-infla...
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Article
Open AccessMolecular identification of Ca(2+)channels in human sperm
The acrosome reaction is a Ca(2+)-dependent exocytotic process that is a prerequisite step for fertilization. External calcium entry through voltage-activated Ca(2+)channels is known to be essential in inducin...
