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  1. Article

    Open Access

    Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

    Striatal projection neurons (SPNs), which progressively degenerate in human patients with Huntington’s disease (HD), are classified along two axes: the canonical direct-indirect pathway division and the strios...

    Ayano Matsushima, Sergio Sebastian Pineda, Jill R. Crittenden… in Nature Communications (2023)

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  2. No Access

    Article

    Single-cell dissection of the human brain vasculature

    Despite the importance of the cerebrovasculature in maintaining normal brain physiology and in understanding neurodegeneration and drug delivery to the central nervous system1, human cerebrovascular cells remain ...

    Francisco J. Garcia, Na Sun, Hyeseung Lee, Brianna Godlewski, Hansruedi Mathys… in Nature (2022)

  3. No Access

    Article

    An amygdala circuit that suppresses social engagement

    Innate social behaviours, such as mating and fighting, are fundamental to animal reproduction and survival1. However, social engagements can also put an individual at risk2. Little is known about the neural mecha...

    Jeong-Tae Kwon, Changhyeon Ryu, Hyeseung Lee, Alec Sheffield, **gxuan Fan… in Nature (2021)

  4. Article

    Open Access

    Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes

    Huntington’s disease (HD) is an incurable neurodegenerative disorder caused by CAG trinucleotide expansions in the huntingtin gene. Markers of both systemic and CNS immune activation and inflammation have been wi...

    Mary H. Wertz, S. Sebastian Pineda, Hyeseung Lee… in Molecular Neurodegeneration (2020)

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  5. No Access

    Article

    Rotational disruption of dust grains by radiative torques in strong radiation fields

    Massive stars, supernovae, and kilonovae are among the most luminous radiation sources in the Universe. Observations usually show near- to mid-infrared (NIR–MIR, λ ≈ 1–5 μm) emission excess from H ii regions arou...

    Thiem Hoang, Le Ngoc Tram, Hyeseung Lee, Sang-Hyeon Ahn in Nature Astronomy (2019)

  6. No Access

    Article

    N6-methyladenosine marks primary microRNAs for processing

    The addition of the N6-methyladenosine (m6A) mark to primary microRNAs by METTL3 in mammalian cells is found to promote the recognition of these microRNA precursors by DGCR8, a component of the microprocessor com...

    Claudio R. Alarcón, Hyeseung Lee, Hani Goodarzi, Nils Halberg, Sohail F. Tavazoie in Nature (2015)

  7. No Access

    Article

    Freezing/thawing processing of PVA in the preparation of structured microspheres for protein drug delivery

    Drug stability and sustained release issues are important areas in drug-delivery research. The sustained release of proteins can be achieved by their encapsulation with a hydrophobic polymer, but this requires...

    MinKyung Lee, Harim Bae, Sona Lee, Nae-oh Chung, Hyeseung Lee… in Macromolecular Research (2011)

  8. No Access

    Article

    Block Copolymer-Based Biomembranes Functionalized with Energy Transduction Proteins

    Block copolymer-based membranes can be functionalized with energy transducing proteins to reveal a versatile family of nanoscale materials. Our work has demonstrated the fabrication of protein-functionalized A...

    Dean Ho, Benjamin Chu, Hyeseung Lee, Karen Kuo… in MRS Online Proceedings Library (2004)